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Capn3 - calpain 3 Gene

Also Known as p94; Lp82; Capa3; Capa-3

Species: Mus musculus

Gene Type: protein coding

Gene ID: 12335

Summary

Enables calcium-dependent cysteine-type endopeptidase activity; metal ion binding activity; and molecular adaptor activity. A structural constituent of muscle. Involved in several processes, including G1 to G0 transition involved in cell differentiation; positive regulation of release of sequestered calcium ion into cytosol; and regulation of transcription, DNA-templated. Acts upstream of or within negative regulation of skeletal muscle cell differentiation; proteolysis; and sarcomere organization. Located in cytosol and plasma membrane. Part of protein-containing complex. Is expressed in several structures, including brain; eye; heart; and musculature. Used to study autosomal recessive limb-girdle muscular dystrophy type 2A. Human ortholog(s) of this gene implicated in autosomal dominant limb-girdle muscular dystrophy; autosomal recessive limb-girdle muscular dystrophy type 2A; and muscular dystrophy. Orthologous to human CAPN3 (calpain 3). [provided by Alliance of Genome Resources, Apr 2022]

Capn3 Products (3)

mRNA	Protein	Name
NM_001109761.2	NP_001103231.1	calpain-3 isoform b
NM_001177799.1	NP_001171270.1	calpain-3 isoform c
NM_007601.3	NP_031627.2	calpain-3 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	20460380	MGI
enables calcium-dependent cysteine-type endopeptidase activity	IDA IDA: Inferred from direct assay	15138196	MGI
enables molecular adaptor activity	IMP IMP: Inferred from mutant phenotype	18676612	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	14741210	MGI
enables sodium ion binding	IDA IDA: Inferred from direct assay	20460380	MGI
enables structural constituent of muscle	IMP IMP: Inferred from mutant phenotype	18676612	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in G1 to G0 transition involved in cell differentiation	IDA IDA: Inferred from direct assay	20139084	MGI
involved in cellular response to calcium ion	IDA IDA: Inferred from direct assay	20460380	MGI
involved in cellular response to salt stress	IDA IDA: Inferred from direct assay	20460380	MGI
involved in muscle structure development	IMP IMP: Inferred from mutant phenotype	18676612	MGI
acts upstream of or within myofibril assembly	IMP IMP: Inferred from mutant phenotype	15138196	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	20139084	MGI
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	18073330	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	18073330	MGI
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	18073330	MGI
involved in positive regulation of proteolysis	IDA IDA: Inferred from direct assay	20139084	MGI
involved in positive regulation of release of sequestered calcium ion into cytosol	IMP IMP: Inferred from mutant phenotype	18676612	MGI
involved in positive regulation of satellite cell activation involved in skeletal muscle regeneration	IDA IDA: Inferred from direct assay	20139084	MGI
involved in programmed cell death	IDA IDA: Inferred from direct assay	20460380	MGI
involved in protein localization to membrane	IMP IMP: Inferred from mutant phenotype	18676612	MGI
involved in protein-containing complex assembly	IMP IMP: Inferred from mutant phenotype	18676612	MGI
acts upstream of or within proteolysis	IDA IDA: Inferred from direct assay	15138196	MGI
involved in proteolysis	IDA IDA: Inferred from direct assay	20460380	MGI
involved in regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	18073330	MGI
involved in regulation of myoblast differentiation	IDA IDA: Inferred from direct assay	20139084	MGI
acts upstream of or within sarcomere organization	IMP IMP: Inferred from mutant phenotype	15138196	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	18073330	MGI
located in cytosol	IDA IDA: Inferred from direct assay	18676612	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	18676612	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	18676612	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
calpain-3	CANP 3 calcium-activated neutral proteinase 3 calpain L3 calpain p94 muscle-specific calcium-activated neutral protease 3 skeletal muscle specific calpain p94

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01890	CAPN3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Capn3	NCBI	NCBI:825