Ctnna2 - catenin (cadherin associated protein), alpha 2 Gene

Also Known as cdf; chp; Catna; Catna2

Species: Mus musculus

Gene Type: protein coding

Gene ID: 12386

Summary

Enables identical protein binding activity. Involved in several processes, including modification of postsynaptic actin cytoskeleton; nervous system development; and prepulse inhibition. Located in several cellular components, including adherens junction; basolateral plasma membrane; and hippocampal mossy fiber to CA3 synapse. Is extrinsic component of postsynaptic membrane and extrinsic component of presynaptic membrane. Is active in parallel fiber to Purkinje cell synapse; postsynaptic density, intracellular component; and presynaptic active zone cytoplasmic component. Is expressed in several structures, including alimentary system; nervous system; reproductive system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in complex cortical dysplasia with Other brain malformations. Orthologous to human CTNNA2 (catenin alpha 2). [provided by Alliance of Genome Resources, Apr 2022]

Ctnna2 Products (4)

mRNA	Protein	Name
NM_001109764.1	NP_001103234.1	catenin alpha-2 isoform 2
NM_001355193.1	NP_001342122.1	catenin alpha-2 isoform 1
NM_009819.2	NP_033949.2	catenin alpha-2 isoform 2
NM_145732.2	NP_663785.2	catenin alpha-2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	23417122	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in axonogenesis	IMP IMP: Inferred from mutant phenotype	16691566	MGI
involved in brain morphogenesis	IMP IMP: Inferred from mutant phenotype	12089526	MGI
involved in dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	12123610	MGI
involved in modification of postsynaptic actin cytoskeleton	IDA IDA: Inferred from direct assay	15034585	MGI
involved in modification of postsynaptic actin cytoskeleton	IMP IMP: Inferred from mutant phenotype	15034585	MGI
involved in prepulse inhibition	IMP IMP: Inferred from mutant phenotype	12089526	MGI
involved in radial glia guided migration of Purkinje cell	IMP IMP: Inferred from mutant phenotype	12089526	MGI
involved in regulation of synapse structural plasticity	IMP IMP: Inferred from mutant phenotype	15034585	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in adherens junction	IDA IDA: Inferred from direct assay	12695331	MGI
located in axon	IMP IMP: Inferred from mutant phenotype	16691566	MGI
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	9950951	MGI
is active in extrinsic component of postsynaptic membrane	IDA IDA: Inferred from direct assay	8909549	MGI
is active in extrinsic component of presynaptic membrane	IDA IDA: Inferred from direct assay	8909549	MGI
is active in hippocampal mossy fiber to CA3 synapse	IDA IDA: Inferred from direct assay	8909549	MGI
located in lamellipodium	IDA IDA: Inferred from direct assay	14657280	MGI
is active in parallel fiber to Purkinje cell synapse	IDA IDA: Inferred from direct assay	8909549	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	17114649	MGI
is active in postsynaptic density, intracellular component	IDA IDA: Inferred from direct assay	8909549	MGI
is active in presynaptic active zone cytoplasmic component	IDA IDA: Inferred from direct assay	8909549	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
catenin alpha-2	alpha(N)-catenin cadherin associated protein cerebellar deficient folia

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03303	CTNNA2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ctnna2	NCBI	NCBI:1496