Cbfa2t2 - CBFA2/RUNX1 translocation partner 2 Gene

Also Known as MTGR1; Cbfa2t2h; A430091M07; C330013D05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12396

Summary

Enables transcription corepressor activity. Involved in intestinal epithelial cell differentiation and negative regulation of Notch signaling pathway. Acts upstream of or within epithelial cell differentiation and negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; blastocyst; brain; genitourinary system; and sensory organ. Orthologous to human CBFA2T2 (CBFA2/RUNX1 partner transcriptional co-repressor 2). [provided by Alliance of Genome Resources, Apr 2022]

Cbfa2t2 Products (3)

mRNA Protein Name
NM_001285446.1 NP_001272375.1 protein CBFA2T2 isoform 3
NM_009823.1 NP_033953.1 protein CBFA2T2 isoform 2
NM_172860.2 NP_766448.1 protein CBFA2T2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16227606 MGI
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
16227606 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within epithelial cell differentiation IMP
IMP: Inferred from mutant phenotype
16227606 MGI
involved in intestinal epithelial cell differentiation IMP
IMP: Inferred from mutant phenotype
25398765 MGI
acts upstream of or within negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
16227606 MGI
involved in negative regulation of Notch signaling pathway IMP
IMP: Inferred from mutant phenotype
25398765 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
19799863 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein CBFA2T2

  • CBFA2T2 identified gene homolog

  • MTG8-like protein

  • MTG8-related protein 1

  • core-binding factor, runt domain, alpha subunit 2, translocated to, 2 homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01993 CBFA2T2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cbfa2t2 NCBI NCBI:9139