Cbln2 - cerebellin 2 precursor protein Gene

Also Known as A730004O05; 6330593N19Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12405

Summary

The protein encoded by this gene belongs to a family of secreted neuronal glycoproteins. The transcript is broadly expressed in the embryonic and adult brain with higher levels in some regions including the olfactory bulb, thalamus, and cerebral cortex. The protein can bind to presynaptic neurexins and induce synaptogenesis in cultured neurons. Null mutant mice are viable, fertile and do not display obvious neuroanatomical defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Cbln2 Products (6)

mRNA Protein Name
NM_001302356.2 NP_001289285.1 cerebellin-2 precursor
NM_001361142.1 NP_001348071.1 cerebellin-2 precursor
NM_001361143.1 NP_001348072.1 cerebellin-2 precursor
NM_001361144.1 NP_001348073.1 cerebellin-2 precursor
NM_001361145.1 NP_001348074.1 cerebellin-2 precursor
NM_172633.4 NP_766221.1 cerebellin-2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17331201 MGI
Biological Process GO Annotation Evidence References Source
involved in maintenance of synapse structure IMP
IMP: Inferred from mutant phenotype
29691328 MGI
acts upstream of or within positive regulation of synapse assembly IDA
IDA: Inferred from direct assay
21356198 MGI
involved in spontaneous synaptic transmission IMP
IMP: Inferred from mutant phenotype
30287486 MGI
acts upstream of synapse assembly IDA
IDA: Inferred from direct assay
21356198 MGI
involved in synapse organization IMP
IMP: Inferred from mutant phenotype
29691328 MGI
involved in trans-synaptic signaling, modulating synaptic transmission IDA
IDA: Inferred from direct assay
29784783 MGI
involved in trans-synaptic signaling, modulating synaptic transmission IEP
IEP: Inferred from expression pattern
36205393 MGI
involved in trans-synaptic signaling, modulating synaptic transmission IMP
IMP: Inferred from mutant phenotype
29784783 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
17331201 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
36205393 MGI
is active in glutamatergic synapse IEP
IEP: Inferred from expression pattern
36205393 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
36205393 MGI
is active in synaptic cleft IDA
IDA: Inferred from direct assay
36205393 MGI
located in synaptic cleft IDA
IDA: Inferred from direct assay
34135511 MGI
is active in synaptic cleft IMP
IMP: Inferred from mutant phenotype
36205393 MGI
part of trans-synaptic protein complex IDA
IDA: Inferred from direct assay
34135511 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cerebellin-2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02002 CBLN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cbln2 NCBI NCBI:147381