Cenpc1 - centromere protein C1 Gene

Also Known as Cenpc; CENP-C

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12617

Summary

This gene encodes a centromeric protein component of a nucleosome-associated complex that plays a central role in kinetochore protein assembly, mitotic progression and chromosome segregation. The human ortholog encodes a protein with DNA-binding activity, that associates constitutively to kinetochores throughout the cell cycle, as part of a prekinetochore complex, together with centromeric protein-A and centromeric protein-B. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

Cenpc1 Products (4)

mRNA Protein Name
NM_001345902.1 NP_001332831.1 centromere protein C isoform 1
NM_001345903.1 NP_001332832.1 centromere protein C isoform 3
NM_001345904.1 NP_001332833.1 centromere protein C isoform 4
NM_007683.4 NP_031709.2 centromere protein C isoform 2

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17218262 MGI
Cellular Component GO Annotation Evidence References Source
located in condensed chromosome, centromeric region IDA
IDA: Inferred from direct assay
15242786 MGI
located in pericentric heterochromatin IDA
IDA: Inferred from direct assay
15242786 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

centromere protein C

  • centromere autoantigen C1

Cenpc1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Cenpc P49452 Pten Mus musculus O08586
Anti Bait CoIP
17218262
Intra
Cenpc P49452 Meikin Mus musculus Q5F2C3
Y2H
25533956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02475 CENPC Human Pre-designed siRNA Set A Pre-designed Set / Unkown