Cradd - CASP2 and RIPK1 domain containing adaptor with death domain Gene

Also Known as RAIDD

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12905

Summary

Predicted to enable death domain binding activity; protease binding activity; and protein-macromolecule adaptor activity. Acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process and positive regulation of apoptotic signaling pathway. Located in cytoplasm and nucleus. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human CRADD (CASP2 and RIPK1 domain containing adaptor with death domain). [provided by Alliance of Genome Resources, Apr 2022]

Cradd Products (8)

mRNA Protein Name
NM_001330138.1 NP_001317067.1 death domain-containing protein CRADD
NM_001330141.1 NP_001317070.1 death domain-containing protein CRADD
NM_001330175.1 NP_001317104.1 death domain-containing protein CRADD
NM_009950.3 NP_034080.1 death domain-containing protein CRADD
NM_001330138.1 NP_001317067.1 death domain-containing protein CRADD
NM_001330141.1 NP_001317070.1 death domain-containing protein CRADD
NM_001330175.1 NP_001317104.1 death domain-containing protein CRADD
NM_009950.3 NP_034080.1 death domain-containing protein CRADD

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process IGI
IGI: Inferred from genetic interaction
16183742 MGI
acts upstream of or within positive regulation of apoptotic signaling pathway IGI
IGI: Inferred from genetic interaction
16183742 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
22279524 MGI
located in nucleus IDA
IDA: Inferred from direct assay
22279524 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

death domain-containing protein CRADD

  • RIP-associated protein with a death domain

  • caspase and RIP adapter with death domain

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03138 CRADD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20004 Cradd Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26507 Cradd Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cradd NCBI NCBI:8738