TYW5 - tRNA-yW synthesizing protein 5 Gene

Also Known as hTYW5; C2orf60

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 129450

About TYW5

Cytogenetic location: 2q33.1 Genomic coordinates (GRCh38): 2:199,928,913-199,955,491 (from NCBI)

This gene has 5 transcripts (splice variants), 198 orthologues and 4 paralogues. Ubiquitous expression in bone marrow (RPKM 2.6), thyroid (RPKM 2.0) and 25 other tissues.

Summary

Enables several functions, including iron ion binding activity; protein homodimerization activity; and tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity. Involved in wybutosine biosynthetic process. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

TYW5 Products (1)

mRNA Protein Name
NM_001039693.3 NP_001034782.1 tRNA wybutosine-synthesizing protein 5

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables iron ion binding IDA
IDA: Inferred from direct assay
20972222 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
20972222 GOA
enables tRNA binding IDA
IDA: Inferred from direct assay
20972222 GOA
enables tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity IDA
IDA: Inferred from direct assay
20739293 GOA
Biological Process GO Annotation Evidence References Source
involved in wybutosine biosynthetic process IDA
IDA: Inferred from direct assay
20739293 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TYW5 Protein Structure

Cupin_8

Cupin_8: Cupin-like domain (17 - 254)

  • 0
  • 100
  • 200
  • 300
  • 315 a.a.
Protein Preferred Names Protein Names

tRNA wybutosine-synthesizing protein 5

  • jmjC domain-containing protein C2orf60

TYW5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TYW5 A2RUC4 POTEF Homo sapiens A5A3E0
Anti Tag CoIP
33961781
Intra
TYW5 A2RUC4 POTEF Homo sapiens A5A3E0
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cerebrooculofacioskeletal Syndrome 4

  • COFS4

  • Cerebro-Oculo-Facio-Skeletal Syndrome 4

  • Cofs Syndrome

  • Cerebrooculofacioskeletal Syndrome, Type 4
Mixed Sleep Apnea

  • Complex Sleep Apnea

  • Sleep Apnea, Mixed Central And Obstructive
Amyotrophic Lateral Sclerosis 7

  • ALS7

  • Amyotrophic Lateral Sclerosis Type 7
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15312 TYW5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TYW5 VGNC VGNC:36555
Mus musculus TYW5 MGD MGI:1915986
Macaca mulatta TYW5 VGNC VGNC:99417
Canis familiaris TYW5 VGNC VGNC:48031
Rattus norvegicus TYW5 RGD RGD:1311269
Others TYW5 NCBI