Cr1l - complement component (3b/4b) receptor 1-like Gene

Also Known as Mcp; Crry; mCRY

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12946

Summary

Predicted to enable Complement Receptor activity and opsonin binding activity. Acts upstream of or within several processes, including cellular response to hypoxia; complement activation; and negative regulation of complement activation. Located in basolateral plasma membrane and external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and liver and biliary system. Human ortholog(s) of this gene implicated in malaria. Orthologous to several human genes including CR1L (complement C3b/C4b receptor 1 like). [provided by Alliance of Genome Resources, Apr 2022]

Cr1l Products (3)

mRNA Protein Name
NM_001355060.1 NP_001341989.1 complement component receptor 1-like protein isoform 2
NM_001355061.1 NP_001341990.1 complement component receptor 1-like protein isoform 3
NM_013499.2 NP_038527.2 complement component receptor 1-like protein isoform 1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to hypoxia IDA
IDA: Inferred from direct assay
20675597 MGI
acts upstream of or within complement activation IMP
IMP: Inferred from mutant phenotype
20675597 MGI
acts upstream of or within in utero embryonic development IGI
IGI: Inferred from genetic interaction
18947875 MGI
acts upstream of or within negative regulation of complement activation IMP
IMP: Inferred from mutant phenotype
10642554 MGI
acts upstream of or within regulation of complement activation IMP
IMP: Inferred from mutant phenotype
18947875 MGI
Cellular Component GO Annotation Evidence References Source
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
20675597 MGI
located in cell surface IDA
IDA: Inferred from direct assay
20675597 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
18947875 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

complement component receptor 1-like protein

  • complement receptor related protein

  • complement regulatory protein Crry

  • protein p65

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03132 CR1L Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cr1l NCBI NCBI:1379