CR1L - complement C3b/C4b receptor 1 like Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1379

About CR1L

Cytogenetic location: 1q32.2 Genomic coordinates (GRCh38): 1:207,645,133-207,723,703 (from NCBI)

This gene has 5 transcripts (splice variants), 21 orthologues and 39 paralogues. Biased expression in bone marrow (RPKM 3.2), appendix (RPKM 1.6) and 5 other tissues.

Summary

Acts upstream of or within regulation of complement activation and regulation of complement-dependent cytotoxicity. Part of receptor complex. [provided by Alliance of Genome Resources, Apr 2022]

CR1L Products (1)

mRNA Protein Name
NM_175710.2 NP_783641.1 complement component receptor 1-like protein precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within regulation of complement activation IDA
IDA: Inferred from direct assay
25284781 GOA
acts upstream of or within regulation of complement-dependent cytotoxicity IDA
IDA: Inferred from direct assay
25284781 GOA
Cellular Component GO Annotation Evidence References Source
part of receptor complex IDA
IDA: Inferred from direct assay
23382219 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CR1L Protein Structure

Sushi

Sushi: Sushi repeat (SCR repeat) (35 - 91)

Sushi

Sushi: Sushi repeat (SCR repeat) (96 - 153)

Sushi

Sushi: Sushi repeat (SCR repeat) (158 - 224)

Sushi

Sushi: Sushi repeat (SCR repeat) (230 - 285)

Sushi

Sushi: Sushi repeat (SCR repeat) (289 - 345)

Sushi

Sushi: Sushi repeat (SCR repeat) (366 - 408)

Sushi

Sushi: Sushi repeat (SCR repeat) (413 - 470)

Sushi

Sushi: Sushi repeat (SCR repeat) (475 - 541)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 569 a.a.
Protein Preferred Names Protein Names

complement component receptor 1-like protein

  • complement C4b-binding protein CR-1-like protein

CR1L Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CR1L Q2VPA4 DDHD1 Homo sapiens Q8NEL9-2
Validated Y2H
32296183
Intra
CR1L Q2VPA4 DDHD1 Homo sapiens Q8NEL9-2
Y2H Prey Pooling
32296183
Intra
CR1L Q2VPA4 DDHD1 Homo sapiens Q8NEL9-2
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Complement Component Receptor 1
Cortisone Reductase Deficiency

  • 11-Alpha Beta-Hydroxysteroid Dehydrogenase Type I Deficiency Of

  • Cortrd

  • Hsd 11b1 Deficiency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03132 CR1L Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CR1L RGD RGD:2399
Mus musculus CR1L MGD MGI:88513
Others CR1L NCBI