Cux2 - cut-like homeobox 2 Gene

Also Known as Cutl2; Cux-2; 1700051K22Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 13048

Summary

This gene is a member of the Cut family of transcription factors that have multiple DNA binding domains and regulate cell proliferation and differentiation. This gene is primarily expressed in nervous tissues where it controls the proliferation of neuronal precursors, and may play a role in organogenesis earlier during embryonic development. Mice lacking the encoded protein exhibit smaller spinal cords with deficits in neural progenitor development as well as in neuroblast and interneuron differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

Cux2 Products (2)

mRNA	Protein	Name
NM_001312908.1	NP_001299837.1	homeobox protein cut-like 2
NM_007804.2	NP_031830.2	homeobox protein cut-like 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	15656993	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	15656993	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15656993	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	20510857	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15656993	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15656993	MGI
involved in positive regulation of dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	20510857	MGI
involved in positive regulation of dendritic spine morphogenesis	IMP IMP: Inferred from mutant phenotype	20510857	MGI
involved in positive regulation of excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	20510857	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	20510857	MGI
involved in positive regulation of synapse assembly	IMP IMP: Inferred from mutant phenotype	20510857	MGI
involved in short-term memory	IMP IMP: Inferred from mutant phenotype	20510857	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	15656993	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
homeobox protein cut-like 2	homeobox protein Cux-2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03370	CUX2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cux2	NCBI	NCBI:23316