2. Gene
  3. Cux2 - cut-like homeobox 2 Gene

Cux2 - cut-like homeobox 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Cutl2; Cux-2; 1700051K22Rik

Gene ID: 13048 | Gene type: protein coding

About Cux2

Summary

This gene is a member of the Cut family of transcription factors that have multiple DNA binding domains and regulate cell proliferation and differentiation. This gene is primarily expressed in nervous tissues where it controls the proliferation of neuronal precursors, and may play a role in organogenesis earlier during embryonic development. Mice lacking the encoded protein exhibit smaller spinal cords with deficits in neural progenitor development as well as in neuroblast and interneuron differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

Cux2 Products(2)

mRNA Protein Name
NM_001312908.1 NP_001299837.1 homeobox protein cut-like 2
NM_007804.2 NP_031830.2 homeobox protein cut-like 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA binding IDA
IDA: Inferred from direct assay
15656993 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
15656993 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15656993 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
IMP: Inferred from mutant phenotype
20510857 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15656993 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15656993 MGI
involved in positive regulation of dendrite morphogenesis IMP
IMP: Inferred from mutant phenotype
20510857 MGI
involved in positive regulation of dendritic spine morphogenesis IMP
IMP: Inferred from mutant phenotype
20510857 MGI
involved in positive regulation of excitatory postsynaptic potential IMP
IMP: Inferred from mutant phenotype
20510857 MGI
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
20510857 MGI
involved in positive regulation of synapse assembly IMP
IMP: Inferred from mutant phenotype
20510857 MGI
involved in short-term memory IMP
IMP: Inferred from mutant phenotype
20510857 MGI
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
15656993 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

homeobox protein cut-like 2

homeobox protein Cux-2

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03370 CUX2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cux2 NCBI NCBI:23316