CUX2 - cut like homeobox 2 Gene

Also Known as CDP2; CUTL2; DEE67; EIEE67

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23316

About CUX2

Cytogenetic location: 12q24.11-q24.12 Genomic coordinates (GRCh38): 12:111,034,165-111,350,554 (from NCBI)

This gene has 3 transcripts (splice variants), 225 orthologues, 1 paralogue and is associated with 3 phenotypes. Biased expression in prostate (RPKM 4.9), liver (RPKM 4.6) and 3 other tissues.

Summary

This gene encodes a protein which contains three CUT domains and a homeodomain; both domains are DNA-binding motifs. A similar gene, whose gene product possesses different DNA-binding activities, is located on chromosome on chromosome 7. Two pseudogenes of this gene have been identified on chromosomes 10 and 4. [provided by RefSeq, Jan 2013]

CUX2 Products (2)

mRNA	Protein	Name
NM_001370598.1	NP_001357527.1	homeobox protein cut-like 2 isoform 2
NM_015267.4	NP_056082.2	homeobox protein cut-like 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15656993	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cognition	IMP IMP: Inferred from mutant phenotype	15389760	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15656993	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	15656993	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CUX2 Protein Structure

CUT

Homeobox

0
300
600
900
1200
1486 a.a.

Protein Preferred Names	Protein Names
homeobox protein cut-like 2	homeobox protein cux-2

Related Diseases

Diseases	Alias
Developmental And Epileptic Encephalopathy 67	DEE67 Epileptic Encephalopathy, Early Infantile, 67 Eiee67 Developmental And Epileptic Encephalopathy, 67 Early Infantile Epileptic Encephalopathy 67
Thrombocythemia 1	THCYT1 Thrombocytosis 1 Thrombocythemia, Somatic Essential Thrombocythemia Thrombocythemia, Essential
Essential Thrombocythemia	Essential Thrombocytosis Familial Thrombocytosis Hemorrhagic Thrombocythemia Hereditary Thrombocythemia Primary Thrombocytosis Idiopathic Thrombocythemia Primary Thrombocythemia Thrombocythemia, Essential Essential Thrombocythaemia Et Familial Thrombocythemia Thrombocythemia Essential
Lennox-Gastaut Syndrome	Lennox Syndrome Encephalopathy Of Childhood Epileptic Encephalopathy Lennox-Gastaut Type Childhood Epileptic Encephalopathy With Diffuse Slow Spikes And Waves Lgs
Fiedler'S Myocarditis	Isolated Myocarditis Fiedler Myocarditis Idiopathic Myocarditis
Developmental And Epileptic Encephalopathy	Encephalopathy, Developmental And Epileptic
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03370	CUX2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CUX2	VGNC	VGNC:82348
Canis familiaris	CUX2	VGNC	VGNC:39739
Rattus norvegicus	CUX2	RGD	RGD:1305967
Bos taurus	CUX2	VGNC	VGNC:27840
Mus musculus	CUX2	MGD	MGI:107321
Macaca mulatta	CUX2	VGNC	VGNC:71443
Others	CUX2	NCBI