IL17RE - interleukin 17 receptor E Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 132014

About IL17RE

Cytogenetic location: 3p25.3 Genomic coordinates (GRCh38): 3:9,902,093-9,916,402 (from NCBI)

This gene has 11 transcripts (splice variants), 180 orthologues and 4 paralogues. Broad expression in duodenum (RPKM 10.6), skin (RPKM 9.9) and 17 other tissues.

Summary

This gene encodes a transmembrane protein that functions as the receptor for interleukin-17C. The encoded protein signals to downstream components of the mitogen activated protein kinase (MAPK) pathway. Activity of this protein is important in the immune response to Bacterial pathogens. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2013]

IL17RE Products (4)

mRNA Protein Name
NM_001193380.2 NP_001180309.1 interleukin-17 receptor E isoform 6 precursor
NM_153480.2 NP_705613.1 interleukin-17 receptor E isoform 1 precursor
NM_153481.2 NP_705614.1 interleukin-17 receptor E isoform 2
NM_153483.2 NP_705616.2 interleukin-17 receptor E isoform 5

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21993848 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL17RE Protein Structure

IL17_R_N

IL17_R_N: Interleukin-17 receptor extracellular region (30 - 448)

SEFIR

SEFIR: SEFIR domain (488 - 561)

SEFIR

SEFIR: SEFIR domain (589 - 626)

  • 0
  • 200
  • 400
  • 600
  • 667 a.a.
Protein Preferred Names Protein Names

interleukin-17 receptor E

  • IL-17 receptor E

IL17RE Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
IL17RE Q8NFR9 IL17RA Homo sapiens Q96F46
Anti Tag CoIP
21993848
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IL17RE Proteins

Cat. No. Product Name Accession Purity
HY-P72576 IL-17RE Protein, Human (HEK293, Fc) Q8NFR9-1 (T155-H454) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Cutaneous Candidiasis

  • Candidiasis, Cutaneous
Seborrheic Infantile Dermatitis

  • Cradle Cap

  • Infantile Seborrhoeic Dermatitis

  • Seborrhoea Capitis

  • Seborrhoeic Dermatitis Of Scalp

  • Seborrhoeic Eczema Of Scalp

  • Complement 5 Dysfunction

  • Generalized Seborrheic Dermatitis Of Infants

  • Infantile Seborrheic Dermatitis

  • Pityriasis Capitis

  • Seborrhea Capitis

  • Seborrhea Sicca

  • Dandruff

  • Complement Component 5 Deficiency

  • Seborrheic Dermatitis

  • Seborrheic Dermatitis Of Scalp

  • Scurfiness Of Scalp

  • Seborrheic Dermatitis Of Infancy

  • Infantile Seborrhoeic Eczema

  • Neonatal Seborrhoeic Dermatitis

  • Infantile Seborrhoeic Dermatitis Of The Scalp
Chronic Mucocutaneous Candidiasis

  • Candidiasis, Chronic Mucocutaneous

  • Cmc

  • Candidiasis Chronic Mucocutaneous
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P5963 Lib2-1 Inhibitor 99.63% Unkown
HY-RS06706 IL17RE Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19064 Il17re Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25554 Il17re Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus IL17RE VGNC VGNC:97464
Mus musculus IL17RE MGD MGI:1889371
Macaca mulatta IL17RE VGNC VGNC:73623
Canis familiaris IL17RE VGNC VGNC:41950
Rattus norvegicus IL17RE RGD RGD:735148
Bos taurus IL17RE VGNC VGNC:30125
Others IL17RE NCBI