Defa3 - defensin, alpha, 3 Gene

Also Known as Defa27; Defcr3; Defcr-3

Species: Mus musculus

Gene Type: protein coding

Gene ID: 13237

Summary

Predicted to enable protein homodimerization activity. Acts upstream of or within response to bacterium and response to xenobiotic stimulus. Located in extracellular space. Orthologous to several human genes including DEFA1 (defensin alpha 1); DEFA3 (defensin alpha 3); and DEFA4 (defensin alpha 4). [provided by Alliance of Genome Resources, Apr 2022]

Defa3 Products (1)

mRNA	Protein	Name
NM_007850.2	NP_031876.1	alpha-defensin 3 precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cellular response to lipopolysaccharide	IGI IGI: Inferred from genetic interaction	11248802	MGI
acts upstream of or within defense response to Gram-negative bacterium	IGI IGI: Inferred from genetic interaction	11248802	MGI
acts upstream of or within defense response to Gram-positive bacterium	IGI IGI: Inferred from genetic interaction	11248802	MGI
acts upstream of or within defense response to bacterium	IDA IDA: Inferred from direct assay	7927786	MGI
acts upstream of or within response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	11248802	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	11248802	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
alpha-defensin 3	defensin, alpha, 27 defensin-related cryptdin-3

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03674	DEFA3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Defa3	NCBI	NCBI:1668