Dmc1 - DNA meiotic recombinase 1 Gene

Also Known as sgdp; Dmc1h; Lim15; Mei11

Species: Mus musculus

Gene Type: protein coding

Gene ID: 13404

Summary

This gene encodes a member of the superfamily of recombinases (also called DNA strand-exchange proteins). Recombinases are important for repairing double-strand DNA breaks during Mitosis and meiosis. This protein, which is evolutionarily conserved, is reported to be essential for meiotic homologous recombination and may thus play an important role in generating diversity of genetic information. In mouse, deficiency of this gene causes infertility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

Dmc1 Products (2)

mRNA	Protein	Name
NM_001278226.1	NP_001265155.1	meiotic recombination protein DMC1/LIM15 homolog isoform 2
NM_010059.3	NP_034189.1	meiotic recombination protein DMC1/LIM15 homolog isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA strand exchange activity	IDA IDA: Inferred from direct assay	17639081	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in double-strand break repair involved in meiotic recombination	IDA IDA: Inferred from direct assay	17639081	MGI
involved in double-strand break repair via homologous recombination	IDA IDA: Inferred from direct assay	17639081	MGI
acts upstream of or within gamete generation	IMP IMP: Inferred from mutant phenotype	12855593	MGI
acts upstream of or within homologous chromosome pairing at meiosis	IMP IMP: Inferred from mutant phenotype	17696610	MGI
acts upstream of or within male meiosis I	IMP IMP: Inferred from mutant phenotype	17696610	MGI
acts upstream of or within oocyte maturation	IMP IMP: Inferred from mutant phenotype	17696610	MGI
acts upstream of or within oogenesis	IGI IGI: Inferred from genetic interaction	15928951	MGI
acts upstream of or within oogenesis	IMP IMP: Inferred from mutant phenotype	15928951	MGI
acts upstream of or within ovarian follicle development	IMP IMP: Inferred from mutant phenotype	15640358	MGI
involved in reciprocal meiotic recombination	IDA IDA: Inferred from direct assay	17639081	MGI
acts upstream of or within spermatid development	IMP IMP: Inferred from mutant phenotype	17696610	MGI
acts upstream of or within spermatogenesis	IGI IGI: Inferred from genetic interaction	15928951	MGI
acts upstream of or within spermatogenesis	IMP IMP: Inferred from mutant phenotype	12855593	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in chromosome	IDA IDA: Inferred from direct assay	21307306	MGI
located in chromosome, telomeric region	IDA IDA: Inferred from direct assay	20336070	MGI
located in condensed nuclear chromosome	IDA IDA: Inferred from direct assay	18283110	MGI
located in lateral element	IDA IDA: Inferred from direct assay	30718482	MGI
located in nucleus	IDA IDA: Inferred from direct assay	21307306	MGI
is active in site of double-strand break	IDA IDA: Inferred from direct assay	30760716	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
meiotic recombination protein DMC1/LIM15 homolog	DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination disrupted meiotic cDNA 1 homolog

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03822	DMC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06167	HID1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dmc1	NCBI	NCBI:11144