2. Gene
  3. Dync1h1 - dynein cytoplasmic 1 heavy chain 1 Gene

Dync1h1 - dynein cytoplasmic 1 heavy chain 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Loa; P22; Swl; DHC1; DNCL; DHC1a; Dnec1; Dnecl; MAP1C; Dnchc1; mKIAA0325; 9930018I23Rik

Gene ID: 13424 | Gene type: protein coding

About Dync1h1

Summary

Enables dynein light intermediate chain binding activity. Involved in P-body assembly; positive regulation of cold-induced thermogenesis; and stress granule assembly. Located in cytoplasm and filopodium. Is expressed in several structures, including early conceptus; nervous system; neural retina; placenta; and spleen. Used to study Charcot-Marie-Tooth disease axonal type 2O. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2O; autosomal dominant non-syndromic intellectual disability 13; and spinal muscular atrophy with lower extremity predominance 1. Orthologous to human DYNC1H1 (dynein cytoplasmic 1 heavy chain 1). [provided by Alliance of Genome Resources, Apr 2022]

Dync1h1 Products(1)

mRNA Protein Name
NM_030238.2 NP_084514.2 cytoplasmic dynein 1 heavy chain 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables dynein light intermediate chain binding IPI
IPI: Inferred from physical interaction
16496424 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16267818 MGI
Biological Process GO Annotation Evidence Reference Source
involved in P-body assembly IMP
IMP: Inferred from mutant phenotype
19825938 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
20887786 MGI
involved in stress granule assembly IMP
IMP: Inferred from mutant phenotype
19825938 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16496424 MGI
located in filopodium IDA
IDA: Inferred from direct assay
16496424 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cytoplasmic dynein 1 heavy chain 1

cytoplasmic dynein heavy chain 1

dynein heavy chain, cytosolic

dynein heavy chain, retrograde transport

dynein, cytoplasmic, heavy chain 1

legs at odd angle

sprawling

Dync1h1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Dync1h1 Q9JHU4 Csf1 Mus musculus P07141
Anti Bait CoIP
16267818
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04082 DYNC1H1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dync1h1 NCBI NCBI:1778