TMEM171 - transmembrane protein 171 Gene

Also Known as PRP2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 134285

About TMEM171

This gene has 2 transcripts (splice variants) and 120 orthologues. Biased expression in colon (RPKM 19.9), thyroid (RPKM 15.7) and 7 other tissues.

Summary

Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMEM171 Products (2)

mRNA Protein Name
NM_001161342.3 NP_001154814.1 transmembrane protein 171 isoform 2
NM_173490.8 NP_775761.4 transmembrane protein 171 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEM171 Protein Structure

TMEM171

TMEM171: Transmembrane protein family 171 (2 - 319)

  • 0
  • 100
  • 200
  • 300
  • 324 a.a.
Protein Preferred Names Protein Names

transmembrane protein 171

  • proline-rich protein PRP2

TMEM171 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TMEM171 Q8WVE6 MIER1 Homo sapiens Q8N108-14
Validated Y2H
25416956
Intra
TMEM171 Q8WVE6 MIER1 Homo sapiens Q8N108-14
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Phosphoribosylpyrophosphate Synthetase Superactivity

  • PRPS1 SUPERACTIVITY

  • Prpp Synthetase Superactivity

  • Gout, Prps-Related

  • Prpp Synthetase Deficiency

  • Prpp Synthetase Overactivity

  • Prs Overactivity

  • Prs Superactivity

  • Mild Phosphoribosylpyrophosphate Synthetase Superactivity

  • Mild Prpp Synthetase Superactivity

  • Mild Prps1 Superactivity

  • Severe Phosphoribosylpyrophosphate Synthetase Superactivity

  • Severe Prpp Synthetase Superactivity

  • Severe Prps1 Superactivity

  • Prps-Related Gout

  • Superactivity, Phosphoribosylpyrophosphate Synthetase
Tubulointerstitial Kidney Disease, Autosomal Dominant, 1

  • Familial Juvenile Hyperuricemic Nephropathy

  • Mckd2

  • Familial Juvenile Hyperuricemic Nephropathy Type 1

  • Fjhn

  • Medullary Cystic Kidney Disease 2

  • Uromodulin-Associated Kidney Disease

  • Medullary Cystic Kidney Disease Type 2

  • ADTKD1

  • Hnfj1

  • Glomerulocystic Kidney Disease With Hyperuricemia And Isosthenuria

  • Adtkd-Umod

  • Familial Juvenile Hyperuricemic Nephropathy 1

  • Umod-Related Adtkd

  • Umod-Related Autosomal Dominant Tubulointerstitial Kidney Disease

  • Hyperuricemic Nephropathy, Familial Juvenile, 1

  • Gouty Nephropathy, Familial Juvenile

  • Medullary Cystic Kidney Disease 2, Autosomal Dominant

  • Admckd2

  • Autosomal Dominant Tubulointerstitial Kidney Disease Due To Umod Mutations

  • Adtkd Due To Umod Mutations

  • Autosomal Dominant Tubulointerstitial Kidney Disease, Umod-Related

  • Autosomal Dominant Medullary Cystic Kidney Disease Type 2

  • Umod-Associated Kidney Disease

  • Uromodulin Kidney Disease

  • Familial Gout-Kidney Disease

  • Familial Gouty Nephropathy

  • Umak

  • Umod-Related Kidney Disease

  • Uromodulin Storage Disease

  • Fjhn1

  • Gouty Nephropathy Familial Juvenile

  • Nephropathy Familial With Gout

  • Hyperuricemic Nephropathy, Familial Juvenile 1

  • Hyperuricemic Nephropathy, Familial Juvenile

  • Kidney Disease, Glomerulocystic, With Hyperuricemia And Isosthenuria

  • Nephropathy, Hyperuricemic, Juvenile, Familial, Type 1

  • Kidney Disease, Cystic, Medullary, Type 2

  • Medullary Cystic Kidney Disease Type Ii

  • Familial Juvenile Gout
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14682 TMEM171 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TMEM171 MGD MGI:2685751
Macaca mulatta TMEM171 VGNC VGNC:79651
Felis catus TMEM171 VGNC VGNC:66289
Bos taurus TMEM171 VGNC VGNC:35996
Rattus norvegicus TMEM171 RGD RGD:1359492
Canis familiaris TMEM171 VGNC VGNC:47497
Others TMEM171 NCBI