Doc2b - double C2, beta Gene

Mus musculus

Gene ID: 13447 | Gene type: protein coding

About Doc2b

Summary

The protein encoded by this gene is a calcium sensor involved in glucose-stimulated Insulin secretion, spontaneous neurotransmitter release, and enhanced SNARE-dependent vesicle fusion. [provided by RefSeq, Sep 2015]

Doc2b Products(1)

mRNA	Protein	Name
NM_007873.3	NP_031899.2	double C2-like domain-containing protein beta

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	21521611	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17548353	MGI
enables syntaxin binding	IPI IPI: Inferred from physical interaction	19033398	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in calcium ion-regulated exocytosis of neurotransmitter	IMP IMP: Inferred from mutant phenotype	20150444	MGI
involved in calcium-dependent activation of synaptic vesicle fusion	IDA IDA: Inferred from direct assay	20150444	MGI
involved in calcium-dependent activation of synaptic vesicle fusion	IMP IMP: Inferred from mutant phenotype	20150444	MGI
involved in positive regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	17548353	MGI
involved in protein localization	IMP IMP: Inferred from mutant phenotype	19033398	MGI
acts upstream of or within spontaneous neurotransmitter secretion	IDA IDA: Inferred from direct assay	21521611	MGI
acts upstream of or within spontaneous neurotransmitter secretion	IGI IGI: Inferred from genetic interaction	21521611	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	19033398	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	19033398	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

double C2-like domain-containing protein beta

doc2-beta

double C2 protein beta

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03920	DOC2B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Doc2b	NCBI	NCBI:8447

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