2. Gene
  3. DOC2B - double C2 domain beta Gene

DOC2B - double C2 domain beta Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as DOC2BL

Gene ID: 8447 | Gene type: protein coding

About DOC2B

Cytogenetic location: 17p13.3 Genomic coordinates (GRCh38): 17:142,789-181,650 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 199 orthologues and 31 paralogues. Ubiquitous expression in brain (RPKM 3.2), bone marrow (RPKM 2.6) and 22 other tissues.

Summary

There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2B is expressed ubiquitously and is suggested to be involved in Ca(2+)-dependent intracellular vesicle trafficking in various types of cells. [provided by RefSeq, Jul 2008]

DOC2B Products(1)

mRNA Protein Name
NM_003585.5 NP_003576.2 double C2-like domain-containing protein beta

DOC2B Protein Structure

C2

C2: C2 domain (143 - 231)

C2

C2: C2 domain (283 - 307)

  • 0
  • 100
  • 200
  • 308 a.a.
Protein Preferred Names Protein Names

double C2-like domain-containing protein beta

doc2-beta

Related Diseases

Diseases Alias
Cataract 8, Multiple Types

Ccv

Cataract, Congenital, Volkmann Type

CTRCT8

Cataract 8 Multiple Types

Cataract Congenital Volkmann Type

Cutaneous Collagenous Vasculopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03920 DOC2B Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta DOC2B VGNC VGNC:71964
Rattus norvegicus DOC2B RGD RGD:620519
Bos taurus DOC2B VGNC VGNC:57140
Canis familiaris DOC2B VGNC VGNC:54939
Mus musculus DOC2B MGD MGI:1100497
Felis catus DOC2B VGNC VGNC:61569