2. Gene
  3. Dsc1 - desmocollin 1 Gene

Dsc1 - desmocollin 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as 1110020A10Rik

Gene ID: 13505 | Gene type: protein coding

About Dsc1

Summary

This gene encodes a member of the Cadherin family of proteins that mediates adhesion in desmosomes. The encoded preproprotein undergoes proteolytic processing to generate the mature, functional protein. Mice lacking the encoded protein exhibit epidermal fragility together with defects of epidermal barrier and differentiation. The neonatal mice lacking the encoded protein exhibit epidermal lesions and older mice develop chronic dermatitis. This gene is located in a cluster of desmosomal Cadherin genes on chromosome 18. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Jan 2016]

Dsc1 Products(2)

mRNA Protein Name
NM_001291804.1 NP_001278733.1 desmocollin-1 isoform 1 preproprotein
NM_013504.5 NP_038532.3 desmocollin-1 isoform 2 precursor
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
12847106 MGI
Cellular Component GO Annotation Evidence Reference Source
located in desmosome IDA
IDA: Inferred from direct assay
14673151 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

desmocollin-1

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04014 DSC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04016 DSC3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11779 RCAN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21728 Rcan1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dsc1 NCBI NCBI:1823