E4f1 - E4F transcription factor 1 Gene

Mus musculus

Also known as p120E4F; phi-AP3

Gene ID: 13560 | Gene type: protein coding

About E4f1

Summary

This gene encodes a member of the GLI-Kruppel zinc finger family. The encoded protein is likely to be multi-functional, with both adenovirus E1A-regulated transcription factor and ubiquitin E3 Ligase activities, including roles in cell cycle regulation and the ubiquitination of p53. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

E4f1 Products(3)

mRNA	Protein	Name
NM_001301784.1	NP_001288713.1	transcription factor E4F1 isoform 1
NM_001355708.1	NP_001342637.1	transcription factor E4F1 isoform 3
NM_007893.4	NP_031919.2	transcription factor E4F1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	15226446	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12198120	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within DNA replication	IMP IMP: Inferred from mutant phenotype	15226446	MGI
acts upstream of or within embryo development	IMP IMP: Inferred from mutant phenotype	15226446	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12198120	MGI
involved in regulation of cell cycle process	IDA IDA: Inferred from direct assay	14645522	MGI
acts upstream of or within regulation of mitotic cell cycle, embryonic	IMP IMP: Inferred from mutant phenotype	15226446	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	15226446	MGI
located in spindle	IDA IDA: Inferred from direct assay	15226446	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transcription factor E4F1

RING-type E3 ubiquitin transferase E4F1	putative E3 ubiquitin-protein ligase E4F1
transcription factor E4F	transcription factor phi AP3

E4f1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	E4f1	Q8CCE9	Anp32a	Mus musculus	O35381	Y2H	17557114
Intra	E4f1	Q8CCE9	Anp32a	Mus musculus	O35381	Anti Bait CoIP	17557114

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04118	E4F1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	E4f1	NCBI	NCBI:1877

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