E4f1 - E4F transcription factor 1 Gene

Also Known as p120E4F; phi-AP3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13560

Summary

This gene encodes a member of the GLI-Kruppel zinc finger family. The encoded protein is likely to be multi-functional, with both adenovirus E1A-regulated transcription factor and ubiquitin E3 Ligase activities, including roles in cell cycle regulation and the ubiquitination of p53. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

E4f1 Products (3)

mRNA Protein Name
NM_001301784.1 NP_001288713.1 transcription factor E4F1 isoform 1
NM_001355708.1 NP_001342637.1 transcription factor E4F1 isoform 3
NM_007893.4 NP_031919.2 transcription factor E4F1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
15226446 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12198120 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within DNA replication IMP
IMP: Inferred from mutant phenotype
15226446 MGI
acts upstream of or within embryo development IMP
IMP: Inferred from mutant phenotype
15226446 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12198120 MGI
involved in regulation of cell cycle process IDA
IDA: Inferred from direct assay
14645522 MGI
acts upstream of or within regulation of mitotic cell cycle, embryonic IMP
IMP: Inferred from mutant phenotype
15226446 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
15226446 MGI
located in spindle IDA
IDA: Inferred from direct assay
15226446 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor E4F1

  • RING-type E3 ubiquitin transferase E4F1

  • putative E3 ubiquitin-protein ligase E4F1

  • transcription factor E4F

  • transcription factor phi AP3

E4f1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
E4f1 Q8CCE9 Anp32a Mus musculus O35381
Y2H
17557114
Intra
E4f1 Q8CCE9 Anp32a Mus musculus O35381
Anti Bait CoIP
17557114
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04118 E4F1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens E4f1 NCBI NCBI:1877