Phc1 - polyhomeotic 1 Gene

Also Known as Edr; Edr1; Mph1; rae28; Rae-28

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13619

Summary

Enables chromatin binding activity. Acts upstream of or within cellular response to Leukemia Inhibitory Factor and cellular response to retinoic acid. Located in nuclear body and sex chromatin. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; nervous system; and sensory organ. Used to study dilated cardiomyopathy and tetralogy of Fallot. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 11. Orthologous to human PHC1 (polyhomeotic homolog 1). [provided by Alliance of Genome Resources, Apr 2022]

Phc1 Products (8)

mRNA Protein Name
NM_001042623.3 NP_001036088.1 polyhomeotic-like protein 1 isoform b
NM_001271579.2 NP_001258508.1 polyhomeotic-like protein 1 isoform a
NM_001355215.2 NP_001342144.1 polyhomeotic-like protein 1 isoform c
NM_001408247.1 NP_001395176.1 polyhomeotic-like protein 1 isoform b
NM_001408248.1 NP_001395177.1 polyhomeotic-like protein 1 isoform b
NM_001408249.1 NP_001395178.1 polyhomeotic-like protein 1 isoform c
NM_001408250.1 NP_001395179.1 polyhomeotic-like protein 1 isoform d
NM_007905.4 NP_031931.2 polyhomeotic-like protein 1 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chromatin binding IDA
IDA: Inferred from direct assay
16687444 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10653359 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
20439489 MGI
acts upstream of or within cellular response to retinoic acid IDA
IDA: Inferred from direct assay
8070621 MGI
Cellular Component GO Annotation Evidence References Source
located in nuclear body IDA
IDA: Inferred from direct assay
12183370 MGI
located in nucleus IDA
IDA: Inferred from direct assay
14557078 MGI
located in sex chromatin IDA
IDA: Inferred from direct assay
15525528 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

polyhomeotic-like protein 1

  • early development regulator1 (homolog of polyhomeotic 1)

  • early development regulatory protein 1

  • polyhomeotic-like 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10409 PHC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Phc1 NCBI NCBI:1911