Enah - ENAH actin regulator Gene

Also Known as Mena; WBP8; Ndpp1; NDPP-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13800

Summary

Enables SH3 domain binding activity and profilin binding activity. Involved in actin filament organization and actin polymerization-dependent cell motility. Acts upstream of or within actin polymerization or depolymerization; cellular response to leukemia inhibitory factor; and nervous system development. Located in several cellular components, including focal adhesion; lamellipodium; and stress fiber. Is expressed in several structures, including branchial arch; early embryo; gonad; limb bud; and nervous system. Orthologous to human ENAH (ENAH actin regulator). [provided by Alliance of Genome Resources, Apr 2022]

Enah Products (4)

mRNA Protein Name
NM_001083120.2 NP_001076589.1 protein enabled homolog isoform 3
NM_001083121.2 NP_001076590.1 protein enabled homolog isoform 4
NM_008680.3 NP_032706.2 protein enabled homolog isoform 2
NM_010135.3 NP_034265.2 protein enabled homolog isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables SH3 domain binding IDA
IDA: Inferred from direct assay
9126384 MGI
enables profilin binding IDA
IDA: Inferred from direct assay
10069337 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
8861907 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within actin cytoskeleton organization IGI
IGI: Inferred from genetic interaction
15371503 MGI
involved in actin filament organization IDA
IDA: Inferred from direct assay
8861907 MGI
acts upstream of or within actin polymerization or depolymerization IDA
IDA: Inferred from direct assay
8861907 MGI
involved in actin polymerization-dependent cell motility IDA
IDA: Inferred from direct assay
8861907 MGI
acts upstream of or within axon guidance IGI
IGI: Inferred from genetic interaction
15371503 MGI
acts upstream of or within axon guidance IMP
IMP: Inferred from mutant phenotype
10069337 MGI
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
20439489 MGI
acts upstream of or within neural tube closure IGI
IGI: Inferred from genetic interaction
10069337 MGI
Cellular Component GO Annotation Evidence References Source
located in filopodium IDA
IDA: Inferred from direct assay
10069337 MGI
located in focal adhesion IDA
IDA: Inferred from direct assay
8861907 MGI
located in lamellipodium IDA
IDA: Inferred from direct assay
12672821 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
10069337 MGI
located in stress fiber IDA
IDA: Inferred from direct assay
8861907 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein enabled homolog

  • NPC derived proline rich protein 1

  • enabled homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04367 ENAH Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Enah NCBI NCBI:55740