ENAH - ENAH actin regulator Gene

Also Known as ENA; MENA; NDPP1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55740

About ENAH

Cytogenetic location: 1q42.12 Genomic coordinates (GRCh38): 1:225,486,829-225,653,878 (from NCBI)

This gene has 10 transcripts (splice variants), 234 orthologues and 5 paralogues. Ubiquitous expression in gall bladder (RPKM 8.3), prostate (RPKM 7.8) and 24 other tissues.

Summary

This gene encodes a member of the enabled/ vasodilator-stimulated phosphoprotein. Members of this gene family are involved in actin-based motility. This protein is involved in regulating the assembly of actin filaments and modulates cell adhesion and motility. Alternate splice variants of this gene have been correlated with tumor invasiveness in certain tissues and these variants may serve as prognostic markers. A pseudogene of this gene is found on chromosome 3. [provided by RefSeq, Sep 2016]

ENAH Products (5)

mRNA Protein Name
NM_001008493.3 NP_001008493.1 protein enabled homolog isoform a
NM_001377481.1 NP_001364410.1 protein enabled homolog isoform c
NM_001377482.1 NP_001364411.1 protein enabled homolog isoform d
NM_001377483.1 NP_001364412.1 protein enabled homolog isoform e
NM_018212.6 NP_060682.2 protein enabled homolog isoform b

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables WW domain binding IPI
IPI: Inferred from physical interaction
17686488 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10801818 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ENAH Protein Structure

WH1

WH1: WH1 domain (4 - 107)

VASP_tetra

VASP_tetra: VASP tetramerisation domain (551 - 590)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 591 a.a.
Protein Preferred Names Protein Names

protein enabled homolog

  • Mena delta 11a

ENAH Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ENAH Q8N8S7 FAT1 Homo sapiens Q14517
ELISA
16979624
Intra
ENAH Q8N8S7 TERF2IP Homo sapiens Q9NYB0
Pull Down
21044950
Intra
ENAH Q8N8S7 TERF2IP Homo sapiens Q9NYB0
BiFC
21044950
Cross: Cross-species interaction Intra: Intraspecies interaction

ENAH Antibodies

Cat. No. Product Name Application Reactivity
HY-P811208 MENA Antibody WB, IHC-P Human, Mouse

Related Diseases

Diseases Alias
Gastric Papillary Adenocarcinoma

  • Papillary Adenocarcinoma Of Stomach
Retinitis Pigmentosa 54

  • RP54

  • Retinitis Pigmentosa, Type 54
Gastric Tubular Adenocarcinoma

  • Tubular Adenocarcinoma Of Stomach
Valproate Embryopathy

  • Fetal Valproate Syndrome

  • Fetal Valproic Acid Syndrome

  • Fvs

  • Valproic Acid Embryopathy

  • Fetal Valproate Spectrum Disorder

  • Valproate Embryopathy, Susceptibility To

  • Foetal Valproate Syndrome

  • Foetal Valproic Acid Syndrome

  • Susceptibility To Valproate Embryopathy

  • Valproic Acid Antenatal Infection
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04367 ENAH Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ENAH VGNC VGNC:61855
Canis familiaris ENAH VGNC VGNC:40357
Rattus norvegicus ENAH RGD RGD:1307666
Macaca mulatta ENAH VGNC VGNC:99903
Bos taurus ENAH VGNC VGNC:59333
Mus musculus ENAH MGD MGI:108360
Others ENAH NCBI