MENA Antibody
(Synonyms: MENA, ENAH, Protein enabled homolog)MENA Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to MENA.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 |
Product Details
MENA Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to MENA.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse
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Observed Molecular WeightObserved band size: 67 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 66 kDa
Synthetic peptide corresponding to the C-term region of human MENA.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Envío
Shipping with blue ice.
Background
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Function
MENA is an Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity)
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Subcellular Localization
Cytoplasm; Cytoplasm, cytoskeleton; Cell projection, lamellipodium; Cell projection, filopodium; Synapse; Cell junction, focal adhesion
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Expression
Tissue_Specificity: Expressed in myoepithelia of parotid, breast, bronchial glands and sweat glands. Expressed in colon-rectum muscolaris mucosae epithelium, pancreas acinar ductal epithelium, endometrium epithelium, prostate fibromuscolar stroma and placenta vascular media. Overexpressed in a majority of breast cancer cell lines and primary breast tumor lesions. -
Isoforms & Post-Translational Modification
MENA has 3 isoforms, Q8N8S7-1: amino acid length is 591, molecular weight is 66510 Da (predicted); Q8N8S7-2: amino acid length is 570, molecular weight is 63924 Da (predicted); Q8N8S7-3: amino acid length is 533, molecular weight is 60349 Da (predicted).NTN1 诱导的第 265 位丝氨酸(Ser-265)PKA 磷酸化与丝状伪足突起的形成直接平行相关MENA 存在 3 个异构体，Q8N8S7-1：氨基酸个数为 591 个，分子量为 66510 Da (预测)；Q8N8S7-2：氨基酸个数为 570 个，分子量为 63924 Da (预测)；Q8N8S7-3：氨基酸个数为 533 个，分子量为 60349 Da (预测)。NTN1-induced PKA phosphorylation on Ser-265 directly parallels the formation of filopodial protrusions
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Subunit
Homotetramer (By similarity).
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SwissProt ID
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Synonyms
MENA, ENAH, Protein enabled homolog
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