PTPDC1 - protein tyrosine phosphatase domain containing 1 Gene

Also Known as PTP9Q22

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 138639

About PTPDC1

This gene has 5 transcripts (splice variants), 201 orthologues and 8 paralogues. Broad expression in testis (RPKM 3.6), adrenal (RPKM 2.2) and 24 other tissues.

Summary

The protein encoded by this gene contains a characteristic motif of Protein tyrosine phosphatases (PTPs). PTPs regulate activities of phosphoproteins through dephosphorylation. They are signaling molecules involved in the regulation of a wide variety of biological processes. The specific function of this protein has not yet been determined. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

PTPDC1 Products (4)

mRNA Protein Name
NM_001253829.2 NP_001240758.1 protein tyrosine phosphatase domain-containing protein 1 isoform 3
NM_001253830.2 NP_001240759.1 protein tyrosine phosphatase domain-containing protein 1 isoform 4
NM_152422.4 NP_689635.3 protein tyrosine phosphatase domain-containing protein 1 isoform 1
NM_177995.3 NP_818931.1 protein tyrosine phosphatase domain-containing protein 1 isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTPDC1 Protein Structure

DSPc

DSPc: Dual specificity phosphatase, catalytic domain (113 - 236)

  • 0
  • 200
  • 400
  • 600
  • 754 a.a.
Protein Preferred Names Protein Names

protein tyrosine phosphatase domain-containing protein 1

  • protein tyrosine phosphatase PTP9Q22

PTPDC1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PTPDC1 A2A3K4 MID2 Homo sapiens Q9UJV3-2
Validated Y2H
32296183
Intra
PTPDC1 A2A3K4 MID2 Homo sapiens Q9UJV3-2
Y2H Array
32296183
Intra
PTPDC1 A2A3K4 MID2 Homo sapiens Q9UJV3-2
Y2H Prey Pooling
32296183
Intra
PTPDC1 A2A3K4 TEX11 Homo sapiens Q8IYF3-3
Y2H Prey Pooling
32296183
Intra
PTPDC1 A2A3K4 TEX11 Homo sapiens Q8IYF3-3
Validated Y2H
32296183
Intra
PTPDC1 A2A3K4 TEX11 Homo sapiens Q8IYF3-3
Y2H Array
32296183
Intra
PTPDC1 A2A3K4 CRKL Homo sapiens P46109
Y2H Array
32296183
Intra
PTPDC1 A2A3K4 CRKL Homo sapiens P46109
Y2H Prey Pooling
32296183
Intra
PTPDC1 A2A3K4 CRKL Homo sapiens P46109
Validated Y2H
32296183
Intra
PTPDC1 A2A3K4 MAPK1 Homo sapiens P28482
Y2H Prey Pooling
32296183
Intra
PTPDC1 A2A3K4 MAPK1 Homo sapiens P28482
Validated Y2H
32296183
Intra
PTPDC1 A2A3K4 MAPK1 Homo sapiens P28482
Y2H Array
32296183
Intra
PTPDC1 A2A3K4 MAPK1 Homo sapiens P28482
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11413 PTPDC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21917 Ptpdc1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PTPDC1 MGD MGI:2145430
Canis familiaris PTPDC1 VGNC VGNC:45165
Bos taurus PTPDC1 VGNC VGNC:33527
Felis catus PTPDC1 VGNC VGNC:64430
Rattus norvegicus PTPDC1 RGD RGD:1307698
Macaca mulatta PTPDC1 VGNC VGNC:76567
Others PTPDC1 NCBI