Nr2f1 - nuclear receptor subfamily 2, group F, member 1 Gene

Also Known as EAR3; EAR-3; SVP44; Erbal3; COUPTFA; COUP-TF1; COUP-TFI; Tcfcoup1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13865

Summary

Enables sequence-specific DNA binding activity. Acts upstream of or within nervous system development and regulation of RNA metabolic process. Located in nucleus. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; gut; and sensory organ. Human ortholog(s) of this gene implicated in Bosch-Boonstra-Schaaf optic atrophy syndrome. Orthologous to human NR2F1 (nuclear receptor subfamily 2 group F member 1). [provided by Alliance of Genome Resources, Apr 2022]

Nr2f1 Products (6)

mRNA Protein Name
NM_001347538.2 NP_001334467.1 COUP transcription factor 1 isoform b
NM_001347539.2 NP_001334468.1 COUP transcription factor 1 isoform c
NM_001403773.1 NP_001390702.1 COUP transcription factor 1 isoform b
NM_001403775.1 NP_001390704.1 COUP transcription factor 1 isoform b
NM_001403777.1 NP_001390706.1 COUP transcription factor 1 isoform b
NM_010151.4 NP_034281.2 COUP transcription factor 1 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
7823919 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cerebral cortex regionalization IMP
IMP: Inferred from mutant phenotype
17828260 MGI
acts upstream of or within forebrain development IDA
IDA: Inferred from direct assay
15548577 MGI
acts upstream of or within interneuron migration IDA
IDA: Inferred from direct assay
15548577 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
7823919 MGI
acts upstream of or within neuron migration IDA
IDA: Inferred from direct assay
15548577 MGI
acts upstream of or within positive regulation of miRNA transcription IMP
IMP: Inferred from mutant phenotype
24349493 MGI
acts upstream of or within regulation of gene expression IGI
IGI: Inferred from genetic interaction
24349493 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
15548577 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

COUP transcription factor 1

  • COUP transcription factor I

  • V-erbA-related protein 3

  • avian erythroblastic leukemia viral (v-erb-a) oncogene homolog-like 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-149913 NR2F1 agonist 1 Antagonist 99.06% Unkown
HY-RS09541 NR2F1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18534 Nr2f1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25016 Nr2f1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nr2f1 NCBI NCBI:7025