NR2F1 agonist 1 

NR2F1 agonist 1, a nuclear receptor NR2F1 agonist, specifically activates dormancy programs in malignant cells. NR2F1 agonist 1 up-regulates NR2F1 and downstream target genes that regulate dormancy. NR2F1 agonist 1 induces neural crest-like and growth suppression in head and neck squamous cell carcinoma (HNSCC) via NR2F1 activation. NR2F1 agonist 1 inhibits tumor growth in a mouse primary tumor model^[1].

NR2F1 agonist 1 (compound C26) (0.5 μM, 1 μM; 18 h) significantly induces luciferase expression in D-HEp3 cells^[1].
NR2F1 agonist 1 (0.5 μM; 7 d) significantly down-regulates the phosphoinositide 3-kinase (PI3K) signaling pathway^[1].
NR2F1 agonist 1 (0.5 μM; 7 d) significantly up-regulates mRNA levels of SOX9, RARβ, and p27^[1].
NR2F1 agonist 1 (0.5 μM; 48 h) induces cell cycle arrest at G0/G1 in D-HEp3 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NR2F1 agonist 1 (0.5 mg/kg/day; i.p.; 3 weeks) inhibits inhibits primary tumor growth and metastatic growth in lungs in mouse models^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

470.63

C₂₈H₃₀N₄OS

374101-64-1

Solid

Off-white to light yellow

O=C1C2=C(N3C(SCC)=NN=C3N1CCC4=CC=CC=C4)C5=C(CC26CCCCC6)C=CC=C5

Room temperature in continental US; may vary elsewhere.

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

• [1]. Khalil BD, et al. An NR2F1-specific agonist suppresses metastasis by inducing cancer cell dormancy. J Exp Med. 2022 Jan 3;219(1):e20210836.  [Content Brief]