SLITRK4 - SLIT and NTRK like family member 4 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 139065

About SLITRK4

Cytogenetic location: Xq27.3 Genomic coordinates (GRCh38): X:143,622,790-143,636,101 (from NCBI)

This gene has 3 transcripts (splice variants), 188 orthologues and 25 paralogues. Biased expression in adrenal (RPKM 4.6), brain (RPKM 4.3) and 9 other tissues.

Summary

This gene encodes a transmembrane protein belonging to the the SLITRK family. These family members include two N-terminal leucine-rich repeat domains similar to those found in the axonal growth-controlling protein SLIT, as well as C-terminal regions similar to neurotrophin receptors. Studies of an homologous protein in mouse suggest that this family member functions to suppress neurite outgrowth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

SLITRK4 Products (3)

mRNA Protein Name
NM_001184749.3 NP_001171678.1 SLIT and NTRK-like protein 4 precursor
NM_001184750.2 NP_001171679.1 SLIT and NTRK-like protein 4 precursor
NM_173078.5 NP_775101.1 SLIT and NTRK-like protein 4 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
Biological Process GO Annotation Evidence References Source
involved in regulation of synapse organization IDA
IDA: Inferred from direct assay
23345436 GOA
involved in regulation of synapse organization IMP
IMP: Inferred from mutant phenotype
23345436 GOA
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
23345436 GOA
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
23345436 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLITRK4 Protein Structure

LRR_8

LRR_8: Leucine rich repeat (62 - 119)

LRR_8

LRR_8: Leucine rich repeat (131 - 190)

LRR_8

LRR_8: Leucine rich repeat (425 - 485)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 837 a.a.
Protein Preferred Names Protein Names

SLIT and NTRK-like protein 4

  • slit and trk like gene 4

SLITRK4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SLITRK4 Q8IW52 CNPY3 Homo sapiens Q9BT09
Anti Tag CoIP
33961781
Intra
SLITRK4 Q8IW52 CNPY3 Homo sapiens Q9BT09
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SLITRK4 Proteins

Cat. No. Product Name Accession Purity
HY-P77207 SLITRK4 Protein, Human (HEK293, His) Q8IW52 (D19-P616) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Supratentorial Primitive Neuroectodermal Tumor

  • Supratentorial Pnet

  • Supratentorial Embryonal Tumor, Not Otherwise Specified

  • Ewings Sarcoma-Primitive Neuroectodermal Tumor
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13376 SLITRK4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20220 Slitrk4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26727 Slitrk4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SLITRK4 MGD MGI:2442509
Macaca mulatta SLITRK4 VGNC VGNC:77762
Rattus norvegicus SLITRK4 RGD RGD:1588563
Bos taurus SLITRK4 VGNC VGNC:34965
Canis familiaris SLITRK4 VGNC VGNC:46509
Others SLITRK4 NCBI