2. Gene
  3. SLITRK4 - SLIT and NTRK like family member 4 Gene

SLITRK4 - SLIT and NTRK like family member 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 139065 | Gene type: protein coding

About SLITRK4

Cytogenetic location: Xq27.3 Genomic coordinates (GRCh38): X:143,622,790-143,636,101 (from NCBI)

This gene has 3 transcripts (splice variants), 188 orthologues and 25 paralogues. Biased expression in adrenal (RPKM 4.6), brain (RPKM 4.3) and 9 other tissues.

Summary

This gene encodes a transmembrane protein belonging to the the SLITRK family. These family members include two N-terminal leucine-rich repeat domains similar to those found in the axonal growth-controlling protein SLIT, as well as C-terminal regions similar to neurotrophin receptors. Studies of an homologous protein in mouse suggest that this family member functions to suppress neurite outgrowth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

SLITRK4 Products(3)

mRNA Protein Name
NM_001184749.3 NP_001171678.1 SLIT and NTRK-like protein 4 precursor
NM_001184750.2 NP_001171679.1 SLIT and NTRK-like protein 4 precursor
NM_173078.5 NP_775101.1 SLIT and NTRK-like protein 4 precursor

SLITRK4 Protein Structure

LRR_8

LRR_8: Leucine rich repeat (62 - 119)

LRR_8

LRR_8: Leucine rich repeat (131 - 190)

LRR_8

LRR_8: Leucine rich repeat (425 - 485)

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  • 837 a.a.
Protein Preferred Names Protein Names

SLIT and NTRK-like protein 4

slit and trk like gene 4

Recombinant SLITRK4 Proteins

Cat. No. Product Name Accession Purity
HY-P77207 SLITRK4 Protein, Human (HEK293, His) Q8IW52 (D19-P616) ≥95%

Related Diseases

Diseases Alias
Supratentorial Primitive Neuroectodermal Tumor

Supratentorial Pnet

Supratentorial Embryonal Tumor, Not Otherwise Specified

Ewings Sarcoma-Primitive Neuroectodermal Tumor
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13376 SLITRK4 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SLITRK4 MGD MGI:2442509
Macaca mulatta SLITRK4 VGNC VGNC:77762
Rattus norvegicus SLITRK4 RGD RGD:1588563
Bos taurus SLITRK4 VGNC VGNC:34965
Canis familiaris SLITRK4 VGNC VGNC:46509
Others SLITRK4 NCBI