Mecom - MDS1 and EVI1 complex locus Gene
Also Known as Jbo; Mds; Evi1; Mds1; Evi-1; Prdm3; Znfpr1b1; Mds1-Evi1; D630039M04Rik
Species: Mus musculus
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and Histone Methyltransferase activity (H3-K9 specific). Involved in hematopoietic stem cell proliferation; heterochromatin organization; and negative regulation of transcription, DNA-templated. Acts upstream of or within several processes, including animal organ development; embryonic limb morphogenesis; and positive regulation of brown fat cell differentiation. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Used to study otitis media. Human ortholog(s) of this gene implicated in myeloid neoplasm. Orthologous to human MECOM (MDS1 and EVI1 complex locus). [provided by Alliance of Genome Resources, Apr 2022]
Mecom Products (5)
| mRNA | Protein | Name |
|---|---|---|
| NM_001361034.3 | NP_001347963.1 | histone-lysine N-methyltransferase MECOM isoform 3 |
| NM_001370768.2 | NP_001357697.1 | histone-lysine N-methyltransferase MECOM isoform 4 |
| NM_001370769.2 | NP_001357698.1 | histone-lysine N-methyltransferase MECOM isoform 5 |
| NM_007963.2 | NP_031989.2 | histone-lysine N-methyltransferase MECOM isoform 1 |
| NM_021442.3 | NP_067417.1 | histone-lysine N-methyltransferase MECOM isoform 2 |
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
histone-lysine N-methyltransferase MECOM |
|
|
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-RS08275 | MECOM Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
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