Slc8a2 - solute carrier family 8 member A2 Gene

Also Known as Ncx2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 140447

Summary

Enables calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration and calcium:sodium antiporter activity. Involved in inorganic cation transmembrane transport; response to vitamin D; and telencephalon development. Acts upstream of or within cellular calcium ion homeostasis. Located in several cellular components, including dendritic spine; microtubule; and neuronal cell body. Is active in postsynapse. Is integral component of mitochondrial membrane and integral component of postsynaptic membrane. Biomarker of brain ischemia and status epilepticus. Orthologous to human SLC8A2 (solute carrier family 8 member A2). [provided by Alliance of Genome Resources, Apr 2022]

Slc8a2 Products (1)

mRNA Protein Name
NM_078619.2 NP_511174.2 sodium/calcium exchanger 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
8021246 RGD
enables calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
8021246 RGD
enables calcium:sodium antiporter activity IDA
IDA: Inferred from direct assay
9486131 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
16679322 RGD
enables sodium ion transmembrane transporter activity IDA
IDA: Inferred from direct assay
8021246 RGD
Biological Process GO Annotation Evidence References Source
involved in calcium ion export across plasma membrane IDA
IDA: Inferred from direct assay
17343909 RGD
involved in calcium ion import across plasma membrane IDA
IDA: Inferred from direct assay
17343909 RGD
involved in calcium ion transmembrane transport IDA
IDA: Inferred from direct assay
8021246 RGD
involved in calcium ion transmembrane transport IGI
IGI: Inferred from genetic interaction
23628073 RGD
involved in calcium ion transport into cytosol IDA
IDA: Inferred from direct assay
9486131 RGD
acts upstream of or within intracellular calcium ion homeostasis IDA
IDA: Inferred from direct assay
22561287 RGD
acts upstream of or within intracellular calcium ion homeostasis IGI
IGI: Inferred from genetic interaction
23628073 RGD
involved in response to vitamin D IEP
IEP: Inferred from expression pattern
20113508 RGD
involved in sodium ion transmembrane transport IDA
IDA: Inferred from direct assay
8021246 RGD
involved in sodium ion transport IDA
IDA: Inferred from direct assay
9486131 RGD
involved in telencephalon development IEP
IEP: Inferred from expression pattern
12502534 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
21118538 RGD
located in cell projection IDA
IDA: Inferred from direct assay
16914199 RGD
located in dendrite IDA
IDA: Inferred from direct assay
23628073 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
16914199 RGD
located in microtubule IDA
IDA: Inferred from direct assay
16914199 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
16914199 RGD
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
16914199 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sodium/calcium exchanger 2

  • Na(+)/Ca(2+)-exchange protein 2

  • solute carrier family 8 (sodium/calcium exchanger), member 2

  • solute carrier family 8 member 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13338 SLC8A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc8a2 NCBI NCBI:6543