Kcnn2 - potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 Gene

Also Known as bc; SK2; fri; SKCA2; KCa2.2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 140492

Summary

Enables small conductance calcium-activated Potassium Channel activity. Involved in membrane repolarization during atrial cardiac muscle cell action potential and potassium ion transmembrane transport. Acts upstream of or within ion transport. Located in several cellular components, including T-tubule; Z disc; and smooth endoplasmic reticulum. Is expressed in brain; heart; and heart ventricle. Used to study Parkinson's disease. Orthologous to human KCNN2 (potassium calcium-activated channel subfamily N member 2). [provided by Alliance of Genome Resources, Apr 2022]

Kcnn2 Products (2)

mRNA Protein Name
NM_001312905.2 NP_001299834.1 small conductance calcium-activated potassium channel protein 2 isoform SK2-L
NM_080465.2 NP_536713.1 small conductance calcium-activated potassium channel protein 2 isoform SK2-S

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
26880549 MGI
enables small conductance calcium-activated potassium channel activity IDA
IDA: Inferred from direct assay
11557517 MGI
enables small conductance calcium-activated potassium channel activity IMP
IMP: Inferred from mutant phenotype
19139040 MGI
Biological Process GO Annotation Evidence References Source
involved in membrane repolarization during atrial cardiac muscle cell action potential IMP
IMP: Inferred from mutant phenotype
19139040 MGI
involved in modulation of chemical synaptic transmission EXP
EXP: Inferred from Experiment
26166566 MGI
involved in modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
26166566 MGI
involved in potassium ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
19139040 MGI
Cellular Component GO Annotation Evidence References Source
located in T-tubule IDA
IDA: Inferred from direct assay
17110593 MGI
located in Z disc IDA
IDA: Inferred from direct assay
17110593 MGI
located in dendritic spine IDA
IDA: Inferred from direct assay
17347645 MGI
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
26166566 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
25565979 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
17347645 MGI
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
25565979 MGI
located in sarcolemma IDA
IDA: Inferred from direct assay
19815520 MGI
located in smooth endoplasmic reticulum IDA
IDA: Inferred from direct assay
17347645 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

small conductance calcium-activated potassium channel protein 2

  • small conductance calcium-activated potassium channel subfamily N member 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07170 KCNN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kcnn2 NCBI NCBI:3781