Kcnn2 - potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 Gene

Mus musculus

Also known as bc; SK2; fri; SKCA2; KCa2.2

Gene ID: 140492 | Gene type: protein coding

About Kcnn2

Summary

Enables small conductance calcium-activated Potassium Channel activity. Involved in membrane repolarization during atrial cardiac muscle cell action potential and potassium ion transmembrane transport. Acts upstream of or within ion transport. Located in several cellular components, including T-tubule; Z disc; and smooth endoplasmic reticulum. Is expressed in brain; heart; and heart ventricle. Used to study Parkinson's disease. Orthologous to human KCNN2 (potassium calcium-activated channel subfamily N member 2). [provided by Alliance of Genome Resources, Apr 2022]

Kcnn2 Products(2)

mRNA	Protein	Name
NM_001312905.2	NP_001299834.1	small conductance calcium-activated potassium channel protein 2 isoform SK2-L
NM_080465.2	NP_536713.1	small conductance calcium-activated potassium channel protein 2 isoform SK2-S

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	26880549	MGI
enables small conductance calcium-activated potassium channel activity	IDA IDA: Inferred from direct assay	11557517	MGI
enables small conductance calcium-activated potassium channel activity	IMP IMP: Inferred from mutant phenotype	19139040	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in membrane repolarization during atrial cardiac muscle cell action potential	IMP IMP: Inferred from mutant phenotype	19139040	MGI
involved in modulation of chemical synaptic transmission	EXP EXP: Inferred from Experiment	26166566	MGI
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	26166566	MGI
involved in potassium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	19139040	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in T-tubule	IDA IDA: Inferred from direct assay	17110593	MGI
located in Z disc	IDA IDA: Inferred from direct assay	17110593	MGI
located in dendritic spine	IDA IDA: Inferred from direct assay	17347645	MGI
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	26166566	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	25565979	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	17347645	MGI
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	25565979	MGI
located in sarcolemma	IDA IDA: Inferred from direct assay	19815520	MGI
located in smooth endoplasmic reticulum	IDA IDA: Inferred from direct assay	17347645	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

small conductance calcium-activated potassium channel protein 2

small conductance calcium-activated potassium channel subfamily N member 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07170	KCNN2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kcnn2	NCBI	NCBI:3781

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