Plxnb2 - plexin B2 Gene

Also Known as Debt; plexin-B2

Species: Mus musculus

Gene Type: protein coding

Gene ID: 140570

Summary

Enables semaphorin receptor activity. Involved in several processes, including nervous system development; regulation of neuron migration; and semaphorin-plexin signaling pathway. Acts upstream of or within positive regulation of axonogenesis. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human PLXNB2 (plexin B2). [provided by Alliance of Genome Resources, Apr 2022]

Plxnb2 Products (3)

mRNA	Protein	Name
NM_001159521.2	NP_001152993.1	plexin-B2 precursor
NM_001284506.1	NP_001271435.1	plexin-B2 precursor
NM_138749.3	NP_620088.2	plexin-B2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12123608	MGI
enables semaphorin receptor activity	IMP IMP: Inferred from mutant phenotype	17554007	MGI
enables transmembrane signaling receptor activity	IDA IDA: Inferred from direct assay	29100074	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in brain development	IMP IMP: Inferred from mutant phenotype	17554007	MGI
involved in excitatory synapse assembly	IMP IMP: Inferred from mutant phenotype	29981480	MGI
involved in neural tube closure	IMP IMP: Inferred from mutant phenotype	17554007	MGI
involved in neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	17554007	MGI
acts upstream of or within positive regulation of axonogenesis	IGI IGI: Inferred from genetic interaction	15330859	MGI
involved in regulation of GTPase activity	IMP IMP: Inferred from mutant phenotype	17554007	MGI
involved in regulation of cell shape	IMP IMP: Inferred from mutant phenotype	17554007	MGI
involved in regulation of neuron migration	IMP IMP: Inferred from mutant phenotype	17554007	MGI
involved in regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	17554007	MGI
involved in semaphorin-plexin signaling pathway	IMP IMP: Inferred from mutant phenotype	17554007	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	21966369	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
plexin-B2	differentially expressed in brain tumors

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10753	PLXNB2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Plxnb2	NCBI	NCBI:23654