PLXNB2 - plexin B2 Gene

Also Known as MM1; PLEXB2; Nbla00445; dJ402G11.3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23654

About PLXNB2

Cytogenetic location: 22q13.33 Genomic coordinates (GRCh38): 22:50,274,979-50,307,646 (from NCBI)

This gene has 12 transcripts (splice variants), 318 orthologues and 8 paralogues. Ubiquitous expression in kidney (RPKM 34.6), spleen (RPKM 29.9) and 25 other tissues.

Summary

Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002) [PubMed 12183458]).[supplied by OMIM, Mar 2008]

PLXNB2 Products (24)

mRNA Protein Name
NM_001376864.1 NP_001363793.1 plexin-B2 isoform 1 precursor
NM_001376865.1 NP_001363794.1 plexin-B2 isoform 2 precursor
NM_001376866.1 NP_001363795.1 plexin-B2 isoform 3 precursor
NM_001376867.1 NP_001363796.1 plexin-B2 isoform 3 precursor
NM_001376868.1 NP_001363797.1 plexin-B2 isoform 3 precursor
NM_001376869.1 NP_001363798.1 plexin-B2 isoform 3 precursor
NM_001376870.1 NP_001363799.1 plexin-B2 isoform 3 precursor
NM_001376871.1 NP_001363800.1 plexin-B2 isoform 3 precursor
NM_001376872.1 NP_001363801.1 plexin-B2 isoform 3 precursor
NM_001376873.1 NP_001363802.1 plexin-B2 isoform 3 precursor
NM_001376874.1 NP_001363803.1 plexin-B2 isoform 3 precursor
NM_001376875.1 NP_001363804.1 plexin-B2 isoform 3 precursor
NM_001376876.1 NP_001363805.1 plexin-B2 isoform 3 precursor
NM_001376877.1 NP_001363806.1 plexin-B2 isoform 3 precursor
NM_001376878.1 NP_001363807.1 plexin-B2 isoform 3 precursor
NM_001376879.1 NP_001363808.1 plexin-B2 isoform 3 precursor
NM_001376880.1 NP_001363809.1 plexin-B2 isoform 3 precursor
NM_001376881.1 NP_001363810.1 plexin-B2 isoform 3 precursor
NM_001376882.1 NP_001363811.1 plexin-B2 isoform 3 precursor
NM_001376883.1 NP_001363812.1 plexin-B2 isoform 4 precursor
NM_001376884.1 NP_001363813.1 plexin-B2 isoform 5 precursor
NM_001376885.1 NP_001363814.1 plexin-B2 isoform 5 precursor
NM_001376886.1 NP_001363815.1 plexin-B2 isoform 7 precursor
NM_012401.4 NP_036533.2 plexin-B2 isoform 3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15184888 GOA
enables transmembrane signaling receptor activity IDA
IDA: Inferred from direct assay
29100074 GOA
Biological Process GO Annotation Evidence References Source
involved in homophilic cell adhesion via plasma membrane adhesion molecules IDA
IDA: Inferred from direct assay
16122393 GOA
involved in positive regulation of neuron projection development IDA
IDA: Inferred from direct assay
16122393 GOA
involved in positive regulation of translation IMP
IMP: Inferred from mutant phenotype
29100074 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLXNB2 Protein Structure

Sema

Sema: Sema domain (35 - 438)

PSI

PSI: Plexin repeat (469 - 516)

TIG

TIG: IPT/TIG domain (803 - 892)

TIG

TIG: IPT/TIG domain (898 - 967)

TIG

TIG: IPT/TIG domain (983 - 1091)

Plexin_cytopl

Plexin_cytopl: Plexin cytoplasmic RasGAP domain (1271 - 1805)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1838 a.a.
Protein Preferred Names Protein Names

plexin-B2

PLXNB2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PLXNB2 O15031 MET Homo sapiens P08581
Anti Bait CoIP
15184888
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PLXNB2 Proteins

Cat. No. Product Name Accession Purity
HY-P78757 Plexin B2 Protein, Human (HEK293, His) O15031-1 (L20-R1160) ≥ 90%, as determined by reducing SDS-PAGE.

PLXNB2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P87044 Plexin B2 Antibody (YA6737) WB, ICC/IF, IHC-P Human

Related Diseases

Diseases Alias
Spinocerebellar Ataxia, X-Linked 5

  • SCAX5

  • X-Linked Spinocerebellar Ataxia 5

  • X-Linked Non Progressive Cerebellar Ataxia
Walker-Warburg Syndrome

  • Hard Syndrome

  • Walker-Warburg Congenital Muscular Dystrophy

  • Cerebroocular Dysplasia-Muscular Dystrophy Syndrome

  • Cod-Md Syndrome

  • Chemke Syndrome

  • Hydrocephalus, Agyria And Retinal Dysplasia

  • Cerebroocular Dysgenesis

  • Cerebroocular Dysplasia Muscular Dystrophy Syndrome

  • Hard +/- E Syndrome

  • Pagon Syndrome

  • Warburg Syndrome

  • Hydrocephalus, Agyria, And Retinal Dysplasia

  • Mddga

  • Muscular Dystrophy-Dystroglycanopathy , Type A

  • Muscular Dystrophy-Dystroglycanopathy [With Brain And Eye Anomalies], Type A

  • Hydrocephalus-Agyria-Retinal Dysplasia Syndrome

  • Wws

  • Dystrophy, Muscular, Dystroglycanopathy, Type A
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10753 PLXNB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PLXNB2 RGD RGD:1305495
Mus musculus PLXNB2 MGD MGI:2154239
Felis catus PLXNB2 VGNC VGNC:68919
Canis familiaris PLXNB2 VGNC VGNC:44723
Bos taurus PLXNB2 VGNC VGNC:33062
Macaca mulatta PLXNB2 VGNC VGNC:76188
Others PLXNB2 NCBI