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NEK7 - NIMA related kinase 7 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 140609

About NEK7

Cytogenetic location: 1q31.3 Genomic coordinates (GRCh38): 1:198,156,998-198,322,420 (from NCBI)

This gene has 8 transcripts (splice variants), 209 orthologues and 8 paralogues. Ubiquitous expression in heart (RPKM 38.5), fat (RPKM 31.8) and 24 other tissues.

Summary

NIMA-related kinases share high amino acid sequence identity with the gene product of the Aspergillus nidulans 'never in Mitosis A' gene, which controls initiation of Mitosis.[supplied by OMIM, Jul 2002]

NEK7 Products (1)

mRNA	Protein	Name
NM_133494.3	NP_598001.1	serine/threonine-protein kinase Nek7

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables molecular function activator activity	IDA IDA: Inferred from direct assay	19941817	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	26188091	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	19941817	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of NLRP3 inflammasome complex assembly	IDA IDA: Inferred from direct assay	31189953	GOA
acts upstream of or within positive regulation of telomere maintenance	IMP IMP: Inferred from mutant phenotype	21531765	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	12840024	GOA
involved in regulation of mitotic cell cycle	IDA IDA: Inferred from direct assay	19941817	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in microtubule organizing center	IDA IDA: Inferred from direct assay	17586473	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NEK7 Protein Structure

Pkinase

0
100
200
302 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein kinase Nek7	NIMA (never in mitosis gene a)-related kinase 7

NEK7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NEK7	Q8TDX7	HUWE1	Homo sapiens	Q7Z6Z7-2	Y2H Pooling	32814053
Intra	NEK7	Q8TDX7	HUWE1	Homo sapiens	Q7Z6Z7-2	Validated Y2H	32814053
Intra	NEK7	Q8TDX7	HUWE1	Homo sapiens	Q7Z6Z7-2	Y2H Array	32814053
Intra	NEK7	Q8TDX7	USP12	Homo sapiens	O75317	Y2H Pooling	32814053
Intra	NEK7	Q8TDX7	USP12	Homo sapiens	O75317	Validated Y2H	32814053
Intra	NEK7	Q8TDX7	USP12	Homo sapiens	O75317	Y2H Array	32814053
Intra	NEK7	Q8TDX7	ISY1	Homo sapiens	Q9ULR0	Validated Y2H	32814053
Intra	NEK7	Q8TDX7	ISY1	Homo sapiens	Q9ULR0	Y2H Array	32814053
Intra	NEK7	Q8TDX7	ISY1	Homo sapiens	Q9ULR0	Y2H Pooling	32814053
Intra	NEK7	Q8TDX7	MGC39372	Homo sapiens	Q8TB02	Validated Y2H	32814053
Intra	NEK7	Q8TDX7	MGC39372	Homo sapiens	Q8TB02	Y2H Array	32814053
Intra	NEK7	Q8TDX7	MGC39372	Homo sapiens	Q8TB02	Y2H Pooling	32814053
Intra	NEK7	Q8TDX7	TMPO	Homo sapiens	P42166	Pull Down	32707033
Intra	NEK7	Q8TDX7	PGK1	Homo sapiens	P00558	Pull Down	32707033
Intra	NEK7	Q8TDX7	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	NEK7	Q8TDX7	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
Intra	NEK7	Q8TDX7	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NEK7 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75935	NEK7 Protein, Human (Inactive, sf9, His-GST)	Q8TDX7-1 (M1-S302)	≥ 90%, as determined by reducing SDS-PAGE.

NEK7 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81615	NEK7 Antibody (YA1360)	WB, IP	Mouse, Rat
HY-P81615A	NEK7 Antibody (YA1360)(PBS only)	WB, IP	Mouse, Rat

Related Diseases

Diseases	Alias
Muckle-Wells Syndrome	MWS Urticaria-Deafness-Amyloidosis Syndrome Uda Syndrome Neutrophilic Urticaria Urticaria, Deafness And Amyloidosis Cryopyrin-Associated Periodic Syndrome 2 Caps2 Muckle Wells Syndrome Urticaria-Deafness-Amyloidosis Cryopyrin-Associated Periodic Syndromes
Cinca Syndrome	CINCA Nomid Cryopyrin-Associated Periodic Syndrome 3 Chronic Neurologic Cutaneous And Articular Syndrome Multisystem Inflammatory Disease, Neonatal-Onset Caps3 Chronic Infantile Neurological Cutaneous Articular Syndrome Infantile-Onset Multisystem Inflammatory Disease Iomid Syndrome Neonatal-Onset Multisystem Inflammatory Disease Nomid Syndrome Prieur-Griscelli Syndrome Neonatal Onset Multisystem Inflammatory Disease Chronic Infantile Neurological, Cutaneous And Articular Syndrome Iomid Infantile Onset Multisystem Inflammatory Disease Prieur Griscelli Syndrome Chronic Infantile Neurological Cutaneous And Articular Syndrome Chronic, Infantile, Neurological, Cutaneous, Articular Syndrome Chronic Infantile Neurologic Cutaneous And Articular Syndrome Chronic Infantile Neurological, Cutaneous, And Articular Syndrome Cryopyrin-Associated Periodic Syndromes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-172162	LC-04-045	Degrader	99.56%	Unkown
HY-159520	Ofirnoflastum	Inhibitor	99.93%	Unkown
HY-173154B	NK7-902 diTFA	Degrader	99.88%	Unkown
HY-175452	MRT-3486	Degrader	99.62%	Unkown
HY-163358	SLC3037	Inhibitor	99.85%	Unkown
HY-176860	NEK7 degrader-1	Degrader	99.94%	Unkown
HY-W998347	ABS-752 hydrochloride		98.81%	Unkown
HY-174270	NLRP3-IN-79	Inhibitor	99.10%	Unkown
HY-168737	NEK7-IN-2	Inhibitor	/	Unkown
HY-185311	NEK7 degrader-3	Degrader	/	Unkown
HY-180890	PPARγ agonist-21	Inhibitor	/	Unkown
HY-177559	NEK7 degrader-2	Degrader	/	Unkown
HY-177433	NEK7 degrader-4	Degrader	/	Unkown
HY-208735	NEK7 degrader-5	Degrader	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NEK7	VGNC	VGNC:107901
Rattus norvegicus	NEK7	RGD	RGD:1311160
Mus musculus	NEK7	MGD	MGI:1890645
Macaca mulatta	NEK7	VGNC	VGNC:81484
Bos taurus	NEK7	VGNC	VGNC:31998
Canis familiaris	NEK7	VGNC	VGNC:43734
Others	NEK7	NCBI