USP12 - ubiquitin specific peptidase 12 Gene

Also Known as UBH1; USP12L1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 219333

About USP12

Cytogenetic location: 13q12.13 Genomic coordinates (GRCh38): 13:27,066,156-27,171,811 (from NCBI)

This gene has 3 transcripts (splice variants), 216 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 15.7), lymph node (RPKM 15.4) and 25 other tissues.

Summary

Enables cysteine-type endopeptidase activity and thiol-dependent Deubiquitinase. Involved in protein deubiquitination. Predicted to be located in nucleoplasm. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

USP12 Products (1)

mRNA Protein Name
NM_182488.4 NP_872294.2 ubiquitin carboxyl-terminal hydrolase 12

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cysteine-type deubiquitinase activity IDA
IDA: Inferred from direct assay
19075014 GOA
enables cysteine-type endopeptidase activity IMP
IMP: Inferred from mutant phenotype
19075014 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19075014 GOA
Biological Process GO Annotation Evidence References Source
involved in protein deubiquitination IDA
IDA: Inferred from direct assay
19075014 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
26811477 GOA
located in nucleus IDA
IDA: Inferred from direct assay
26811477 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
30466959 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP12 Protein Structure

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (38 - 366)

  • 0
  • 100
  • 200
  • 300
  • 370 a.a.
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase 12

  • deubiquitinating enzyme 12

USP12 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
USP12 O75317 WDR20 Homo sapiens Q8TBZ3
Y2H Prey Pooling
32296183
Intra
USP12 O75317 WDR20 Homo sapiens Q8TBZ3
Validated Y2H
32296183
Intra
USP12 O75317 WDR20 Homo sapiens Q8TBZ3
Anti Tag CoIP
19615732
Intra
USP12 O75317 WDR20 Homo sapiens Q8TBZ3
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15523 USP12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18554 Usp12 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25036 Usp12 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta USP12 VGNC VGNC:106312
Mus musculus USP12 MGD MGI:1270128
Bos taurus USP12 VGNC VGNC:52840
Felis catus USP12 VGNC VGNC:66866
Canis familiaris USP12 VGNC VGNC:55012
Rattus norvegicus USP12 RGD RGD:1308045
Others USP12 NCBI