TMPO - thymopoietin Gene

Homo sapiens

Also known as TP; LAP2; CMD1T; LEMD4; PRO0868

Gene ID: 7112 | Gene type: protein coding

About TMPO

Cytogenetic location: 12q23.1 Genomic coordinates (GRCh38): 12:98,515,573-98,550,351 (from NCBI)

This gene has 13 transcripts (splice variants), 280 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in lymph node (RPKM 23.3), bone marrow (RPKM 19.4) and 25 other tissues.

Summary

Through alternative splicing, this gene encodes several distinct LEM domain containing protein isoforms. LEM domain proteins include inner nuclear membrane and intranuclear proteins, and are involved in a variety of cellular functions including gene expression, chromatin organization, and replication and cell cycle control. The encoded alpha isoform is broadly diffuse in the nucleus and contains a lamin binding domain, while the beta and gamma isoforms are localized to the nuclear membrane and contain an HDAC3 interaction domain. The distinct isoforms may compete with each other when acting to chaperone other proteins and regulate transcription. [provided by RefSeq, Aug 2019]

TMPO Products(4)

mRNA	Protein	Name
NM_001032283.3	NP_001027454.1	thymopoietin isoform beta
NM_001032284.3	NP_001027455.1	thymopoietin isoform gamma
NM_001307975.2	NP_001294904.1	thymopoietin isoform delta
NM_003276.2	NP_003267.1	thymopoietin isoform alpha

TMPO Protein Structure

Thymopoietin

LEM

LAP2alpha

0
200
400
600
694 a.a.

Protein Preferred Names

Protein Names

thymopoietin

LEM domain containing 4

Recombinant TMPO Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71361	Thymopoietin Protein, Human (His)	P42167 (M1-E187)	≥95%

Related Diseases

Diseases

Alias

Familial Isolated Dilated Cardiomyopathy

Familial Or Idiopathic Dilated Cardiomyopathy

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

Emery-Dreifuss Muscular Dystrophy

Edmd	Emery-Dreifuss Syndrome
Muscular Dystrophy, Emery-Dreifuss	Humeroperoneal Neuromuscular Disease
Muscular Dystrophy, Tardive, Dreifuss-Emery Type, With Contractures	Scapuloperoneal Syndrome, X-Linked
Benign Scapuloperoneal Muscular Dystrophy With Early Contractures	Muscular Dystrophy, Emery-Dreifuss Type
Muscular Dystrophy Emery-Dreifuss	Dystrophy, Muscular, Emery-Dreifuss
Emd - [Emery-Dreifuss Muscular Dystrophy]

Bronchitis

Chronic Bronchitis	Acute Bronchitis
Bronchitis, Chronic	Acute Bronchitis And Bronchiolitis
Chest Cold	Chest Infection
Ci - Chest Infection	Recurrent Wheezy Bronchitis
Bronchitis Chronic	Lower Respiratory Tract Infection
Acute Lower Respiratory Tract Infection	Chronic Bronchitis Nos
Senile Bronchitis	Bronchitis Nos In Those Under L5 Years Of Age
Bronchitis Nos

Myasthenia Gravis

MG	Acquired Myasthenia
Autoimmune Myasthenia Gravis	Erb-Goldflam Disease
Mg - [Myasthenia Gravis]	Myasthenia Gravis Nos
Myasthenia

Dysentery

Infectious Diarrhea

Reynolds Syndrome

Primary Biliary Cirrhosis, Scleroderma, Raynaud Disease, And Telangiectasia	Primary Biliary Cirrhosis And Systemic Scleroderma
REYNS	Primary Biliary Cirrhosis Scleroderma Raynaud Disease And Telangiectasia

Herpes Zoster

Shingles	Zoster
Herpes Zona	Herpes Zoster Disease
Zona Zoster	Herpes Zoster Of Skin And Mucous Membranes
Zoster Nos	Zoster With Nervous System Involvement

Arrhythmogenic Right Ventricular Dysplasia, Familial, 1

Arrhythmogenic Right Ventricular Dysplasia 1	Uhl Anomaly
Arrhythmogenic Right Ventricular Cardiomyopathy 1	Arvc1
ARVD1	Cardiomyopathy Right Ventricular Dilated
Dysplasia, Arrhythmogenic Right Ventricular, Type 1

Muscular Dystrophy

Muscular Dystrophies	Congenital Md
Congenital Muscular Dystrophy	Cmd
Mdc	Dystrophy, Muscular
Gower'S Muscular Dystrophy	Progressive Musclular Dystrophy
Pseudohypertrophic Atrophy	Pseudohypertrophic Muscle Paralysis
Pseudohypertrophic Muscular Atrophy	Pseudohypertrophic Muscular Dystrophy
Pseudohypertrophic Paralysis	Pseudomuscular Hypertrophy

Dermatitis, Atopic

Atopic Dermatitis	Atopic Eczema
Dermatitis, Atopic, Susceptibility To, 1	Atod
Eczema, Atopic	Dermatitis, Atopic 1
Allergic Dermatitis	Atopic Neurodermatitis
Besnier'S Prurigo	Dermatitis, Atopic, 1
Dermatitis Atopic	Eczema
Besnier Prurigo

Neuromuscular Disease

Neuromuscular Diseases	Neuromuscular Disorders
Neuromuscular Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14762	TMPO Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TMPO	RGD	RGD:3875
Mus musculus	TMPO	MGD	MGI:106920
Bos taurus	TMPO	VGNC	VGNC:36138
Macaca mulatta	TMPO	VGNC	VGNC:78574
Canis familiaris	TMPO	VGNC	VGNC:47627
Felis catus	TMPO	VGNC	VGNC:97665
Others	TMPO	NCBI