TMPO - thymopoietin Gene

Also Known as TP; LAP2; CMD1T; LEMD4; PRO0868

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7112

About TMPO

Cytogenetic location: 12q23.1 Genomic coordinates (GRCh38): 12:98,515,573-98,550,351 (from NCBI)

This gene has 13 transcripts (splice variants), 280 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in lymph node (RPKM 23.3), bone marrow (RPKM 19.4) and 25 other tissues.

Summary

Through alternative splicing, this gene encodes several distinct LEM domain containing protein isoforms. LEM domain proteins include inner nuclear membrane and intranuclear proteins, and are involved in a variety of cellular functions including gene expression, chromatin organization, and replication and cell cycle control. The encoded alpha isoform is broadly diffuse in the nucleus and contains a lamin binding domain, while the beta and gamma isoforms are localized to the nuclear membrane and contain an HDAC3 interaction domain. The distinct isoforms may compete with each Other when acting to chaperone Other proteins and regulate transcription. [provided by RefSeq, Aug 2019]

TMPO Products (4)

mRNA Protein Name
NM_001032283.3 NP_001027454.1 thymopoietin isoform beta
NM_001032284.3 NP_001027455.1 thymopoietin isoform gamma
NM_001307975.2 NP_001294904.1 thymopoietin isoform delta
NM_003276.2 NP_003267.1 thymopoietin isoform alpha

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16247757 GOA
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
17284516 GOA
located in nuclear envelope IDA
IDA: Inferred from direct assay
25468996 GOA
located in nucleus IDA
IDA: Inferred from direct assay
17284516 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMPO Protein Structure

Thymopoietin

Thymopoietin: Thymopoietin protein (2 - 50)

LEM

LEM: LEM domain (110 - 152)

LAP2alpha

LAP2alpha: Lamina-associated polypeptide 2 alpha (461 - 694)

  • 0
  • 200
  • 400
  • 600
  • 694 a.a.
Protein Preferred Names Protein Names

thymopoietin

  • LEM domain containing 4

TMPO Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TMPO P42166 NEK7 Homo sapiens Q8TDX7
Anti Tag CoIP
32707033
Intra
TMPO P42166 LMNA Homo sapiens P02545
Pull Down
16247757
Intra
TMPO P42167 STOM Homo sapiens P27105
Y2H Prey Pooling
32296183
Intra
TMPO P42167 STOM Homo sapiens P27105
Y2H Array
32296183
Intra
TMPO P42167 KLHL6 Homo sapiens Q8WZ60
Validated Y2H
32296183
Intra
TMPO P42167 GOLM1 Homo sapiens Q8NBJ4
Y2H Array
32296183
Intra
TMPO P42167 GOLM1 Homo sapiens Q8NBJ4
Y2H Prey Pooling
32296183
Intra
TMPO P42167 GOLM1 Homo sapiens Q8NBJ4
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TMPO Proteins

Cat. No. Product Name Accession Purity
HY-P71361 Thymopoietin Protein, Human (His) P42167 (M1-E187) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Familial Isolated Dilated Cardiomyopathy

  • Familial Or Idiopathic Dilated Cardiomyopathy
Dilated Cardiomyopathy

  • Familial Dilated Cardiomyopathy

  • Primary Dilated Cardiomyopathy

  • Idiopathic Dilated Cardiomyopathy

  • Congestive Cardiomyopathy

  • Idiopathic Dilation Cardiomyopathy

  • Primary Familial Dilated Cardiomyopathy

  • Cardiomyopathy, Dilated

  • DCM

  • Cardiomyopathy, Familial Dilated

  • Dilated Cardiomyopathy, Familial

  • Hypokinetic Dilated Cardiomyopathy, Familial

  • Familial Idiopathic Cardiomyopathy

  • Fdc

  • Cardiomyopathy, Familial Idiopathic

  • Idiopathic Cardiomegaly

  • Dilated Congestive Cardiomyopathy

  • Chronic Dilated Cardiomyopathy

  • Ccm - [Congestive Cardiomyopathy]

  • Cocm - [Congestive Cardiomyopathy]

  • Dcm - [Dilated Cardiomyopathy]

  • Dilated-Hypokinetic Cardiomyopathy

  • Congestive Idiopathic Cardiomyopathy

  • Primary Idiopathic Dilated Cardiomyopathy
Emery-Dreifuss Muscular Dystrophy

  • Edmd

  • Emery-Dreifuss Syndrome

  • Muscular Dystrophy, Emery-Dreifuss

  • Humeroperoneal Neuromuscular Disease

  • Muscular Dystrophy, Tardive, Dreifuss-Emery Type, With Contractures

  • Scapuloperoneal Syndrome, X-Linked

  • Benign Scapuloperoneal Muscular Dystrophy With Early Contractures

  • Muscular Dystrophy, Emery-Dreifuss Type

  • Muscular Dystrophy Emery-Dreifuss

  • Dystrophy, Muscular, Emery-Dreifuss

  • Emd - [Emery-Dreifuss Muscular Dystrophy]
Bronchitis

  • Chronic Bronchitis

  • Acute Bronchitis

  • Bronchitis, Chronic

  • Acute Bronchitis And Bronchiolitis

  • Chest Cold

  • Chest Infection

  • Ci - Chest Infection

  • Recurrent Wheezy Bronchitis

  • Bronchitis Chronic

  • Lower Respiratory Tract Infection

  • Acute Lower Respiratory Tract Infection

  • Chronic Bronchitis Nos

  • Senile Bronchitis

  • Bronchitis Nos In Those Under L5 Years Of Age

  • Bronchitis Nos
Myasthenia Gravis

  • MG

  • Acquired Myasthenia

  • Autoimmune Myasthenia Gravis

  • Erb-Goldflam Disease

  • Mg - [Myasthenia Gravis]

  • Myasthenia Gravis Nos

  • Myasthenia
Dysentery

  • Infectious Diarrhea
Reynolds Syndrome

  • Primary Biliary Cirrhosis, Scleroderma, Raynaud Disease, And Telangiectasia

  • Primary Biliary Cirrhosis And Systemic Scleroderma

  • REYNS

  • Primary Biliary Cirrhosis Scleroderma Raynaud Disease And Telangiectasia
Herpes Zoster

  • Shingles

  • Zoster

  • Herpes Zona

  • Herpes Zoster Disease

  • Zona Zoster

  • Herpes Zoster Of Skin And Mucous Membranes

  • Zoster Nos

  • Zoster With Nervous System Involvement
Arrhythmogenic Right Ventricular Dysplasia, Familial, 1

  • Arrhythmogenic Right Ventricular Dysplasia 1

  • Uhl Anomaly

  • Arrhythmogenic Right Ventricular Cardiomyopathy 1

  • Arvc1

  • ARVD1

  • Cardiomyopathy Right Ventricular Dilated

  • Dysplasia, Arrhythmogenic Right Ventricular, Type 1
Muscular Dystrophy

  • Muscular Dystrophies

  • Congenital Md

  • Congenital Muscular Dystrophy

  • Cmd

  • Mdc

  • Dystrophy, Muscular

  • Gower'S Muscular Dystrophy

  • Progressive Musclular Dystrophy

  • Pseudohypertrophic Atrophy

  • Pseudohypertrophic Muscle Paralysis

  • Pseudohypertrophic Muscular Atrophy

  • Pseudohypertrophic Muscular Dystrophy

  • Pseudohypertrophic Paralysis

  • Pseudomuscular Hypertrophy
Dermatitis, Atopic

  • Atopic Dermatitis

  • Atopic Eczema

  • Dermatitis, Atopic, Susceptibility To, 1

  • Atod

  • Eczema, Atopic

  • Dermatitis, Atopic 1

  • Allergic Dermatitis

  • Atopic Neurodermatitis

  • Besnier'S Prurigo

  • Dermatitis, Atopic, 1

  • Dermatitis Atopic

  • Eczema

  • Besnier Prurigo
Neuromuscular Disease

  • Neuromuscular Diseases

  • Neuromuscular Disorders

  • Neuromuscular Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14762 TMPO Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W271506 TMPO 99.87% Unkown
HY-RS20829 Tmpo Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27343 Tmpo Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TMPO RGD RGD:3875
Mus musculus TMPO MGD MGI:106920
Bos taurus TMPO VGNC VGNC:36138
Macaca mulatta TMPO VGNC VGNC:78574
Canis familiaris TMPO VGNC VGNC:47627
Felis catus TMPO VGNC VGNC:97665
Others TMPO NCBI