KLHL6 - kelch like family member 6 Gene

Homo sapiens

Gene ID: 89857 | Gene type: protein coding

About KLHL6

Cytogenetic location: 3q27.1 Genomic coordinates (GRCh38): 3:183,487,551-183,555,706 (from NCBI)

This gene has 4 transcripts (splice variants), 87 orthologues and 54 paralogues. Biased expression in lymph node (RPKM 24.5), appendix (RPKM 11.9) and 10 other tissues.

Summary

This gene encodes a member of the kelch-like (KLHL) family of proteins, which is involved in B-lymphocyte antigen receptor signaling and germinal-center B-cell maturation. The encoded protein contains an N-terminal broad-complex, tramtrack and bric a brac (BTB) domain that facilitates protein binding and dimerization, a BTB and C-terminal kelch (BACK) domain, and six C-terminal kelch repeat domains. Naturally occurring mutations in this gene are associated with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]

KLHL6 Products(1)

mRNA	Protein	Name
NM_130446.4	NP_569713.2	kelch-like protein 6

KLHL6 Protein Structure

BTB

BACK

Kelch_1

0
100
200
300
400
500
621 a.a.

Protein Preferred Names

Protein Names

kelch-like protein 6

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07370	KLHL6 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	KLHL6	MGD	MGI:2686922
Bos taurus	KLHL6	VGNC	VGNC:30669
Macaca mulatta	KLHL6	VGNC	VGNC:74077
Felis catus	KLHL6	VGNC	VGNC:63157
Rattus norvegicus	KLHL6	RGD	RGD:1307521
Canis familiaris	KLHL6	VGNC	VGNC:42475

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