KLHL6 - kelch like family member 6 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 89857

About KLHL6

Cytogenetic location: 3q27.1 Genomic coordinates (GRCh38): 3:183,487,551-183,555,706 (from NCBI)

This gene has 4 transcripts (splice variants), 87 orthologues and 54 paralogues. Biased expression in lymph node (RPKM 24.5), appendix (RPKM 11.9) and 10 other tissues.

Summary

This gene encodes a member of the kelch-like (KLHL) family of proteins, which is involved in B-lymphocyte antigen receptor signaling and germinal-center B-cell maturation. The encoded protein contains an N-terminal broad-complex, tramtrack and bric a brac (BTB) domain that facilitates protein binding and dimerization, a BTB and C-terminal kelch (BACK) domain, and six C-terminal kelch repeat domains. Naturally occurring mutations in this gene are associated with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]

KLHL6 Products (1)

mRNA Protein Name
NM_130446.4 NP_569713.2 kelch-like protein 6

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25036637 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLHL6 Protein Structure

BTB

BTB: BTB/POZ domain (64 - 167)

BACK

BACK: BTB And C-terminal Kelch (174 - 276)

Kelch_1

Kelch_1: Kelch motif (414 - 454)

Kelch_1

Kelch_1: Kelch motif (459 - 503)

Kelch_1

Kelch_1: Kelch motif (548 - 583)

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  • 621 a.a.
Protein Preferred Names Protein Names

kelch-like protein 6

KLHL6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
KLHL6 Q8WZ60 FH Homo sapiens P07954
Y2H Array
32296183
Intra
KLHL6 Q8WZ60 FH Homo sapiens P07954
Y2H Prey Pooling
32296183
Intra
KLHL6 Q8WZ60 TMPO Homo sapiens P42167
Y2H Prey Pooling
32296183
Intra
KLHL6 Q8WZ60 TMPO Homo sapiens P42167
Y2H Array
32296183
Intra
KLHL6 Q8WZ60 PPP1R1B Homo sapiens Q9UD71
Validated Y2H
25416956
Intra
KLHL6 Q8WZ60 PPP1R1B Homo sapiens Q9UD71
Y2H Array
25416956
Intra
KLHL6 Q8WZ60 NUDCD3 Homo sapiens Q8IVD9
Anti Tag CoIP
33961781
Intra
KLHL6 Q8WZ60 NUDCD3 Homo sapiens Q8IVD9
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

KLHL6 Antibodies

Cat. No. Product Name Application Reactivity
HY-P86282 KLHL6 Antibody (YA5974) WB, ICC/IF, IP Human

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07370 KLHL6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07371 KLHL7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22601 Klhl6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus KLHL6 MGD MGI:2686922
Bos taurus KLHL6 VGNC VGNC:30669
Macaca mulatta KLHL6 VGNC VGNC:74077
Felis catus KLHL6 VGNC VGNC:63157
Rattus norvegicus KLHL6 RGD RGD:1307521
Canis familiaris KLHL6 VGNC VGNC:42475
Others KLHL6 NCBI