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Cat. No.: HY-208735

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NEK7 degrader-5

NEK7 degrader-5 is a NEK7 degrader. NEK7 degrader-5 inhibits the release of proinflammatory cytokines IL-1β and IL-18. NEK7 degrader-5 can be used for the research of inflammatory and tumor diseases.

For research use only. We do not sell to patients.

CAS No.: 3120512-57-1
Formula: C₃₃H₃₀ClN₅O₃
Molecular Weight:580.08

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

NEK7 degrader-5 Chemical Structure

CAS No.: 3120512-57-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

NEK7

IL-1β

IL-18

All NEKs Isoforms :

All Interleukin Related Isoforms :

In Vitro

NEK7 degrader-5 (LC‑05‑096) degrades NEK7 in NEK7-N-HiBiT engineered MOLT4 cells, with a DC₅₀ > 500 nM and no detectable maximum degradation level^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3120512-57-1
Molecular Weight 580.08
Formula C₃₃H₃₀ClN₅O₃
SMILES

CN1C(CC[C@H](N2CC3=C(C2=O)C=CC(C4=CN=C5CN(CCN45)CC6=C(C7=C(Cl)C=CC=C7)C=CC=C6)=C3)C1=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Jiang Baishan, et al. Imidazolidine heterocyclic compounds and their uses. CN121652155A. 2026-03-13.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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NEK7 degrader-5

All NEKs Isoforms

All Interleukin Related Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

NEK7 degrader-5 Related Classifications

HY-208735 Related Classifications