Cacng3 - calcium voltage-gated channel auxiliary subunit gamma 3 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 140724

Summary

Enables PDZ domain binding activity and ionotropic glutamate receptor binding activity. Involved in positive regulation of AMPA Receptor activity. Located in dendrite; excitatory synapse; and postsynaptic density membrane. Part of AMPA glutamate receptor complex. Is active in glutamatergic synapse. Is integral component of postsynaptic density membrane. Human ortholog(s) of this gene implicated in childhood absence epilepsy and macular degeneration. Orthologous to human CACNG3 (calcium voltage-gated channel auxiliary subunit gamma 3). [provided by Alliance of Genome Resources, Apr 2022]

Cacng3 Products (1)

mRNA Protein Name
NM_080691.2 NP_542422.1 voltage-dependent calcium channel gamma-3 subunit

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables PDZ domain binding IDA
IDA: Inferred from direct assay
15001777 RGD
enables ionotropic glutamate receptor binding IDA
IDA: Inferred from direct assay
12771129 RGD
Biological Process GO Annotation Evidence References Source
involved in positive regulation of AMPA receptor activity IDA
IDA: Inferred from direct assay
12771129 RGD
involved in regulation of AMPA receptor activity IDA
IDA: Inferred from direct assay
17880894 RGD
Cellular Component GO Annotation Evidence References Source
part of AMPA glutamate receptor complex IDA
IDA: Inferred from direct assay
19265014 RGD
located in dendrite IDA
IDA: Inferred from direct assay
15001777 RGD
located in excitatory synapse IDA
IDA: Inferred from direct assay
15001777 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
12771129 RGD
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
12771129 RGD
located in postsynaptic density membrane IDA
IDA: Inferred from direct assay
12771129 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

voltage-dependent calcium channel gamma-3 subunit

  • TARP gamma-3

  • calcium channel, voltage-dependent, gamma subunit 3

  • neuronal voltage-gated calcium channel gamma-3 subunit

  • transmembrane AMPAR regulatory protein gamma-3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01811 CACNG3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cacng3 NCBI NCBI:10368