Arhgef5 - Rho guanine nucleotide exchange factor 5 Gene

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including activation of GTPase activity; positive regulation of JUN kinase activity; and positive regulation of stress fiber assembly. Predicted to act upstream of or within several processes, including hematopoietic stem cell homeostasis; myeloid dendritic cell chemotaxis; and positive regulation of podosome assembly. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in cytoplasm and nucleus. Orthologous to human ARHGEF5 (Rho guanine nucleotide exchange factor 5). [provided by Alliance of Genome Resources, Apr 2022]