2. Gene
  3. Afap1 - actin filament associated protein 1 Gene

Afap1 - actin filament associated protein 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Afap

Gene ID: 140935 | Gene type: protein coding

About Afap1

Summary

Enables SH2 domain binding activity and SH3 domain binding activity. Involved in cellular response to mechanical stimulus and regulation of signal transduction. Located in actin filament. Human ortholog(s) of this gene implicated in open-angle glaucoma. Orthologous to human AFAP1 (actin filament associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Afap1 Products(1)

mRNA Protein Name
NM_080900.2 NP_543176.2 actin filament-associated protein 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables SH2 domain binding IPI
IPI: Inferred from physical interaction
12114187 RGD
enables SH3 domain binding IPI
IPI: Inferred from physical interaction
12114187 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
12114187 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to mechanical stimulus IEP
IEP: Inferred from expression pattern
12114187 RGD
involved in regulation of signal transduction IDA
IDA: Inferred from direct assay
12114187 RGD
Cellular Component GO Annotation Evidence Reference Source
located in actin filament IDA
IDA: Inferred from direct assay
12114187 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

actin filament-associated protein 1

110 kDa actin filament-associated protein

AFAP-110

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00425 AFAP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00426 AFAP1L2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Afap1 NCBI NCBI:60312