Smc2 - structural maintenance of chromosomes 2 Gene

Also Known as CAPE; CAP-E; Fin16; SMC-2; Smc2l1; 5730502P04Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14211

Summary

The protein encoded by this gene is a component of both condensin I and condensin II complexes, and forms a heterodimer with structural maintenance of chromosome 4 (Smc4). This heterodimer is the catalytic subunit for both condensin complexes, and is involved in several processes, including chromosome condensation during Mitosis and meiosis, cohesin removal during Mitosis and meiosis, and single-strand break (SSB) repair. Reduced expression of this gene results in chromosome segregation defects during Mitosis and meiosis, with a more severe defect observed in embryonic stem cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]

Smc2 Products (2)

mRNA Protein Name
NM_001301412.1 NP_001288341.1 structural maintenance of chromosomes protein 2
NM_008017.4 NP_032043.3 structural maintenance of chromosomes protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chromatin binding IDA
IDA: Inferred from direct assay
23531880 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15102471 MGI
enables single-stranded DNA binding IDA
IDA: Inferred from direct assay
20139420 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within kinetochore organization IMP
IMP: Inferred from mutant phenotype
21795393 MGI
acts upstream of or within meiotic chromosome condensation IMP
IMP: Inferred from mutant phenotype
21795393 MGI
acts upstream of or within meiotic chromosome segregation IMP
IMP: Inferred from mutant phenotype
21795393 MGI
involved in positive regulation of chromosome segregation IMP
IMP: Inferred from mutant phenotype
25474630 MGI
involved in positive regulation of chromosome separation IMP
IMP: Inferred from mutant phenotype
21795393 MGI
Cellular Component GO Annotation Evidence References Source
located in condensed chromosome IDA
IDA: Inferred from direct assay
21795393 MGI
located in condensed nuclear chromosome IDA
IDA: Inferred from direct assay
25474630 MGI
part of condensin complex IDA
IDA: Inferred from direct assay
21795393 MGI
part of condensin complex IPI
IPI: Inferred from physical interaction
25474630 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

structural maintenance of chromosomes protein 2

  • FGF-inducible protein 16

  • SMC protein 2

  • SMC2 structural maintenance of chromosomes 2-like 1

  • XCAP-E homolog

  • chromosome-associated protein E

  • fibroblast growth factor inducible 16

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11547 RAB33B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13418 SMC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Smc2 NCBI NCBI:10592