Flii - flightless I actin binding protein Gene

Also Known as Fliih; 3632430F08Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14248

Summary

This gene encodes a protein with gelsolin-like repeats and an N-terminal leucine-rich repeat domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. This protein may act as an actin-remodelling protein as well as a transcriptional coactivator. Homozygous knockout mice show embryonic lethality. This protein may act to regulate wound repair. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

Flii Products (2)

mRNA Protein Name
NM_001302207.1 NP_001289136.1 protein flightless-1 homolog isoform 2
NM_022009.2 NP_071292.1 protein flightless-1 homolog isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18588881 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within multicellular organism development IMP
IMP: Inferred from mutant phenotype
11971982 MGI
involved in sarcomere organization IMP
IMP: Inferred from mutant phenotype
37126682 MGI
Cellular Component GO Annotation Evidence References Source
located in brush border IDA
IDA: Inferred from direct assay
22114352 MGI
located in podosome IDA
IDA: Inferred from direct assay
23525008 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein flightless-1 homolog

  • cytoskeletal actin-modulating protein

  • flightless I homolog

Flii Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Flii Q9JJ28 Camk2d Mus musculus Q6PHZ2
Anti Bait CoIP
18588881
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04978 FLII Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Flii NCBI NCBI:2314