Srgap2 - SLIT-ROBO Rho GTPase activating protein 2 Gene

Also Known as FBP2; Fnbp2; srGAP3; 9930124L22Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 14270

Summary

Enables GTPase activator activity; protein homodimerization activity; and small GTPase binding activity. Involved in plasma membrane bounded cell projection organization and positive regulation of GTPase activity. Located in several cellular components, including phagocytic vesicle; postsynaptic density; and postsynaptic membrane. Is expressed in several structures, including brain; eye; future spinal cord; heart; and spinal cord. Orthologous to human SRGAP2 (SLIT-ROBO Rho GTPase activating protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Srgap2 Products (1)

mRNA	Protein	Name
NM_001081011.2	NP_001074480.2	SLIT-ROBO Rho GTPase-activating protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GTPase activator activity	IDA IDA: Inferred from direct assay	19737524	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8605874	MGI
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	19737524	MGI
enables small GTPase binding	IDA IDA: Inferred from direct assay	19737524	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in dendritic spine development	IMP IMP: Inferred from mutant phenotype	22559944	MGI
involved in excitatory synapse assembly	IMP IMP: Inferred from mutant phenotype	27373832	MGI
involved in extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration	IMP IMP: Inferred from mutant phenotype	19737524	MGI
involved in filopodium assembly	IDA IDA: Inferred from direct assay	19737524	MGI
involved in inhibitory synapse assembly	IMP IMP: Inferred from mutant phenotype	27373832	MGI
involved in neuron projection morphogenesis	IMP IMP: Inferred from mutant phenotype	19737524	MGI
involved in positive regulation of GTPase activity	IDA IDA: Inferred from direct assay	19737524	MGI
involved in regulation of cell migration	IDA IDA: Inferred from direct assay	26439400	MGI
involved in regulation of synapse assembly	IDA IDA: Inferred from direct assay	22559944	MGI
involved in regulation of synapse assembly	IMP IMP: Inferred from mutant phenotype	22559944	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	21148482	MGI
is active in dendritic spine	IDA IDA: Inferred from direct assay	27373832	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	22559944	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	22559944	MGI
located in phagocytic vesicle	IDA IDA: Inferred from direct assay	21148482	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	19737524	MGI
is active in postsynaptic density	IDA IDA: Inferred from direct assay	22559944	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	22559944	MGI
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	22559944	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
SLIT-ROBO Rho GTPase-activating protein 2	FBP-27 formin binding protein 2 formin-binding protein 27

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13763	SRGAP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13764	SRGAP2C Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13765	SRGAP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Srgap2	NCBI	NCBI:23380