Fzd3 - frizzled class receptor 3 Gene

Mus musculus

Also known as Fz3; D930050A07Rik

Gene ID: 14365 | Gene type: protein coding

About Fzd3

Summary

Enables Wnt-activated receptor activity. Involved in negative regulation of execution phase of apoptosis; negative regulation of mitotic cell cycle, embryonic; and nervous system development. Acts upstream of or within several processes, including hair follicle development; nervous system development; and post-anal tail morphogenesis. Located in several cellular components, including apical plasma membrane; filopodium tip; and lateral plasma membrane. Colocalizes with presynaptic active zone. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Used to study hydrocephalus. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome and schizophrenia. Orthologous to human FZD3 (Frizzled class receptor 3). [provided by Alliance of Genome Resources, Apr 2022]

Fzd3 Products(1)

mRNA	Protein	Name
NM_021458.2	NP_067433.1	frizzled-3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables Wnt receptor activity	IMP IMP: Inferred from mutant phenotype	21106844	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16687519	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in Wnt signaling pathway, planar cell polarity pathway	IMP IMP: Inferred from mutant phenotype	21106844	MGI
acts upstream of or within cell proliferation in midbrain	IGI IGI: Inferred from genetic interaction	19842188	MGI
acts upstream of or within commissural neuron axon guidance	IMP IMP: Inferred from mutant phenotype	14671310	MGI
involved in dopaminergic neuron axon guidance	IMP IMP: Inferred from mutant phenotype	21106844	MGI
acts upstream of or within establishment of planar polarity	IGI IGI: Inferred from genetic interaction	16495441	MGI
involved in hair follicle development	IEP IEP: Inferred from expression pattern	11407985	MGI
acts upstream of or within inner ear morphogenesis	IGI IGI: Inferred from genetic interaction	16495441	MGI
acts upstream of or within midbrain development	IGI IGI: Inferred from genetic interaction	19842188	MGI
acts upstream of or within motor neuron migration	IMP IMP: Inferred from mutant phenotype	20631168	MGI
involved in negative regulation of execution phase of apoptosis	IMP IMP: Inferred from mutant phenotype	21325504	MGI
involved in negative regulation of mitotic cell cycle, embryonic	IMP IMP: Inferred from mutant phenotype	21325504	MGI
acts upstream of or within neural tube closure	IGI IGI: Inferred from genetic interaction	16495441	MGI
involved in positive regulation of neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	21325504	MGI
acts upstream of or within post-anal tail morphogenesis	IMP IMP: Inferred from mutant phenotype	21746835	MGI
involved in serotonergic neuron axon guidance	IMP IMP: Inferred from mutant phenotype	21106844	MGI
involved in sympathetic ganglion development	IMP IMP: Inferred from mutant phenotype	21325504	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical part of cell	IDA IDA: Inferred from direct assay	16495441	MGI
located in apical plasma membrane	IDA IDA: Inferred from direct assay	20016102	MGI
located in axon	IDA IDA: Inferred from direct assay	18986540	MGI
located in dendrite	IDA IDA: Inferred from direct assay	18986540	MGI
located in filopodium tip	IDA IDA: Inferred from direct assay	24305805	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	34407949	MGI
located in lateral plasma membrane	IDA IDA: Inferred from direct assay	20473291	MGI
located in neuronal cell body	IDA IDA: Inferred from direct assay	18986540	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	15035989	MGI
colocalizes with presynaptic active zone	IDA IDA: Inferred from direct assay	18986540	MGI
is active in presynaptic active zone membrane	IDA IDA: Inferred from direct assay	34407949	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

frizzled-3

frizzled homolog 3	fz-3
mFz3

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05179	FZD3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05185	FZD9 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fzd3	NCBI	NCBI:7976

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