Fzd3 - frizzled class receptor 3 Gene

Also Known as Fz3; D930050A07Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14365

Summary

Enables Wnt-activated receptor activity. Involved in negative regulation of execution phase of apoptosis; negative regulation of mitotic cell cycle, embryonic; and nervous system development. Acts upstream of or within several processes, including hair follicle development; nervous system development; and post-anal tail morphogenesis. Located in several cellular components, including apical plasma membrane; filopodium tip; and lateral plasma membrane. Colocalizes with presynaptic active zone. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Used to study hydrocephalus. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome and schizophrenia. Orthologous to human FZD3 (Frizzled class receptor 3). [provided by Alliance of Genome Resources, Apr 2022]

Fzd3 Products (1)

mRNA Protein Name
NM_021458.2 NP_067433.1 frizzled-3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables Wnt receptor activity IMP
IMP: Inferred from mutant phenotype
21106844 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16687519 MGI
Biological Process GO Annotation Evidence References Source
involved in Wnt signaling pathway, planar cell polarity pathway IMP
IMP: Inferred from mutant phenotype
21106844 MGI
acts upstream of or within cell proliferation in midbrain IGI
IGI: Inferred from genetic interaction
19842188 MGI
acts upstream of or within commissural neuron axon guidance IMP
IMP: Inferred from mutant phenotype
14671310 MGI
involved in dopaminergic neuron axon guidance IMP
IMP: Inferred from mutant phenotype
21106844 MGI
acts upstream of or within establishment of planar polarity IGI
IGI: Inferred from genetic interaction
16495441 MGI
involved in hair follicle development IEP
IEP: Inferred from expression pattern
11407985 MGI
acts upstream of or within inner ear morphogenesis IGI
IGI: Inferred from genetic interaction
16495441 MGI
acts upstream of or within midbrain development IGI
IGI: Inferred from genetic interaction
19842188 MGI
acts upstream of or within motor neuron migration IMP
IMP: Inferred from mutant phenotype
20631168 MGI
involved in negative regulation of execution phase of apoptosis IMP
IMP: Inferred from mutant phenotype
21325504 MGI
involved in negative regulation of mitotic cell cycle, embryonic IMP
IMP: Inferred from mutant phenotype
21325504 MGI
acts upstream of or within neural tube closure IGI
IGI: Inferred from genetic interaction
16495441 MGI
involved in positive regulation of neuroblast proliferation IMP
IMP: Inferred from mutant phenotype
21325504 MGI
acts upstream of or within post-anal tail morphogenesis IMP
IMP: Inferred from mutant phenotype
21746835 MGI
involved in serotonergic neuron axon guidance IMP
IMP: Inferred from mutant phenotype
21106844 MGI
involved in sympathetic ganglion development IMP
IMP: Inferred from mutant phenotype
21325504 MGI
Cellular Component GO Annotation Evidence References Source
located in apical part of cell IDA
IDA: Inferred from direct assay
16495441 MGI
located in apical plasma membrane IDA
IDA: Inferred from direct assay
20016102 MGI
located in axon IDA
IDA: Inferred from direct assay
18986540 MGI
located in dendrite IDA
IDA: Inferred from direct assay
18986540 MGI
located in filopodium tip IDA
IDA: Inferred from direct assay
24305805 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
34407949 MGI
located in lateral plasma membrane IDA
IDA: Inferred from direct assay
20473291 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
18986540 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
15035989 MGI
colocalizes with presynaptic active zone IDA
IDA: Inferred from direct assay
18986540 MGI
is active in presynaptic active zone membrane IDA
IDA: Inferred from direct assay
34407949 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

frizzled-3

  • frizzled homolog 3

  • fz-3

  • mFz3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05179 FZD3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05185 FZD9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fzd3 NCBI NCBI:7976