FZD3 - frizzled class receptor 3 Gene

Also Known as Fz-3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7976

About FZD3

Cytogenetic location: 8p21.1 Genomic coordinates (GRCh38): 8:28,494,212-28,574,258 (from NCBI)

This gene has 4 transcripts (splice variants), 276 orthologues and 15 paralogues. Broad expression in brain (RPKM 6.0), ovary (RPKM 2.6) and 18 other tissues.

Summary

This gene is a member of the Frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. Most Frizzled receptors are coupled to the beta-catenin canonical signaling pathway. The function of this protein is unknown, although it may play a role in mammalian hair follicle development. Alternative splicing results in multiple transcript variants. This gene is a susceptibility locus for schizophrenia. [provided by RefSeq, Dec 2010]

FZD3 Products (18)

mRNA Protein Name
NM_001412905.1 NP_001399834.1 frizzled-3 isoform 2 precursor
NM_001412906.1 NP_001399835.1 frizzled-3 isoform 3
NM_001412907.1 NP_001399836.1 frizzled-3 isoform 4 precursor
NM_001412908.1 NP_001399837.1 frizzled-3 isoform 5
NM_001412909.1 NP_001399838.1 frizzled-3 isoform 6
NM_001412910.1 NP_001399839.1 frizzled-3 isoform 6
NM_001412911.1 NP_001399840.1 frizzled-3 isoform 1 precursor
NM_001412912.1 NP_001399841.1 frizzled-3 isoform 7
NM_001412913.1 NP_001399842.1 frizzled-3 isoform 7
NM_001412917.1 NP_001399846.1 frizzled-3 isoform 2 precursor
NM_001412919.1 NP_001399848.1 frizzled-3 isoform 6
NM_001412921.1 NP_001399850.1 frizzled-3 isoform 8 precursor
NM_001412922.1 NP_001399851.1 frizzled-3 isoform 9
NM_001412924.1 NP_001399853.1 frizzled-3 isoform 10
NM_001412925.1 NP_001399854.1 frizzled-3 isoform 10
NM_001412927.1 NP_001399856.1 frizzled-3 isoform 11
NM_017412.4 NP_059108.1 frizzled-3 precursor
NM_145866.2 NP_665873.1 frizzled-3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables PDZ domain binding IPI
IPI: Inferred from physical interaction
18256285 GOA
enables Wnt-protein binding IPI
IPI: Inferred from physical interaction
19038973 GOA
Biological Process GO Annotation Evidence References Source
involved in canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
20802536 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
19038973 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
19038973 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FZD3 Protein Structure

Fz

Fz: Fz domain (28 - 134)

Frizzled

Frizzled: Frizzled/Smoothened family membrane region (192 - 515)

  • 0
  • 200
  • 400
  • 600
  • 666 a.a.
Protein Preferred Names Protein Names

frizzled-3

  • frizzled 3, seven transmembrane spanning receptor

FZD3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P811190 Frizzled 3 Antibody WB, ICC/IF Human, Mouse

Related Diseases

Diseases Alias
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Multicystic Dysplastic Kidney

  • Multicystic Renal Dysplasia

  • Multicystic Kidney Dysplasia

  • Mcdk

  • Multiple Congenital Cysts Of Kidney

  • Developmental Multicystic Kidney
Hydrocephalus

  • Hydrocephalus, Nonsyndromic, Autosomal Recessive

  • Hydrocephalus, X-Linked

  • Hydrocephalus Adverse Event

  • Hydrocephaly Nos
Fallopian Tube Serous Adenocarcinoma
Distal Arthrogryposis

  • Arthrogryposis Multiplex Congenita

  • Arthrogryposis

  • Congenital Multiple Arthrogryposis

  • Congenital Arthromyodysplasia

  • Fibrous Ankylosis Of Multiple Joints

  • Guerin-Stern Syndrome

  • Guérin-Stern Syndrome

  • Myodystrophia Fetalis Deformans

  • Otto Syndrome

  • Rocher-Sheldon Syndrome

  • Rossi Syndrome

  • Amc

  • Multiple Congenital Arthrogryposis

  • Arthrogryposis Syndrome

  • Arthrogryposis, Distal

  • Distal Arthrogryposis Syndrome

  • Freeman-Sheldon Syndrome

  • Arthrogryposis, Distal, Type 2b

  • Congenital Multiplex Arthrogryposis

  • Amyoplasia Congenita

  • Congenital Amyoplasia

  • Amc - [Arthrogryposis Multiplex Congenita]
Neural Tube Defects

  • Spina Bifida

  • Neural Tube Defect

  • NTD

  • Neural Tube Defects, Susceptibility To

  • Spinal Dysraphism

  • Spina Bifida, Susceptibility To

  • Rachischisis

  • Cleft Spine

  • Open Spine

  • Hydrocele Spinalis

  • Neural Tube Defect Nos

  • Sb - [Spina Bifida]

  • Spinal Hernia Nos

  • Spinal Fissure Nos
Schizophrenia

  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1
Fallopian Tube Adenocarcinoma

  • Adenocarcinoma Of The Fallopian Tube
Schizophrenia 19

  • SCZD19

  • Schizophrenia 19 With Or Without An Affective Disorder

  • Schizophrenia 19, Susceptibility To

  • {Schizophrenia 19, Susceptibility To}
Substance-Induced Psychosis
Tethered Spinal Cord Syndrome

  • Spinal Dysraphism

  • Tethered Cord Syndrome

  • Occult Spinal Dysraphism

  • Occult Spinal Dysraphism Sequence

  • Segmental Vertebral Anomalies

  • Tethered Spinal Cord Disease

  • Tethered Cord

  • Spina Bifida Occulta

  • Cryptomerorachischisis

  • Spina Bifida Occulta With Tethered Spinal Cord

  • Sbo - [Spina Bifida Occulta]
Robinow Syndrome

  • Acral Dysostosis With Facial And Genital Abnormalities

  • Fetal Face Syndrome

  • Robinow Dwarfism

  • Mesomelic Dwarfism-Small Genitalia Syndrome

  • Robinow-Silverman-Smith Syndrome

  • Costovertebral Segmentation Defect With Mesomelia

  • Covesdem Syndrome

  • Robinow'S Syndrome

  • Robinow-Silverman Syndrome
Strabismus

  • Strabismus, Susceptibility To

  • Strabismus, Susceptibility To, 1

  • Strabismus 1
Hirschsprung Disease 1

  • Hirschsprung Disease

  • Aganglionic Megacolon

  • Hscr

  • Hirschsprung'S Disease

  • Congenital Megacolon

  • Congenital Intestinal Aganglionosis

  • Colonic Aganglionosis

  • Hirschsprung Disease, Susceptibility To, 1

  • Hirschsprung Disease, Protection Against

  • HSCR1

  • Mgc

  • Pelvirectal Achalasia

  • Total Intestinal Aganglionosis

  • Megacolon, Aganglionic

  • Macrocolon

  • Hscr 1

  • Hirschsprung Disease Type 1

  • Hirschsprung Disease, Type 1

  • Congenital Dilatation Of Colon

  • Aganglionosis

  • Congenital Aganglionic Megacolon

  • Aganglionosis Of Colon

  • Bowel Aganglionosis

  • Colon Aganglionosis

  • Hirschsprung Megacolon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05179 FZD3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05185 FZD9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris FZD3 VGNC VGNC:41031
Rattus norvegicus FZD3 RGD RGD:628814
Bos taurus FZD3 VGNC VGNC:58460
Mus musculus FZD3 MGD MGI:108476
Felis catus FZD3 VGNC VGNC:62405
Macaca mulatta FZD3 VGNC VGNC:72835
Others FZD3 NCBI