SESN3 - sestrin 3 Gene

Also Known as SEST3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 143686

About SESN3

Cytogenetic location: 11q21 Genomic coordinates (GRCh38): 11:95,165,513-95,232,475 (from NCBI)

This gene has 6 transcripts (splice variants), 161 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 14.9), lymph node (RPKM 14.4) and 24 other tissues.

Summary

This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular Reactive Oxygen Species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FOXO transcription factor. The protein is required for normal regulation of blood glucose, Insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]

SESN3 Products (2)

mRNA Protein Name
NM_001271594.2 NP_001258523.1 sestrin-3 isoform 2
NM_144665.4 NP_653266.2 sestrin-3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25263562 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to amino acid starvation IMP
IMP: Inferred from mutant phenotype
25263562 GOA
involved in cellular response to glucose starvation IMP
IMP: Inferred from mutant phenotype
25263562 GOA
involved in negative regulation of TORC1 signaling IMP
IMP: Inferred from mutant phenotype
25263562 GOA
Cellular Component GO Annotation Evidence References Source
part of GATOR2 complex IDA
IDA: Inferred from direct assay
25263562 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
25263562 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SESN3 Protein Structure

PA26

PA26: PA26 p53-induced protein (sestrin) (38 - 492)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 492 a.a.
Protein Preferred Names Protein Names

sestrin-3

Related Diseases

Diseases Alias
Endometrial Adenosquamous Carcinoma

  • Adenosquamous Carcinoma Of Endometrium

  • Adenosquamous Carcinoma Of The Endometrium

  • Endometrial Adenosquamous Cancer

  • Endometrial Adenosquamous Cell Carcinoma
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-175352 Nurr1 agonist 14 99.42% Unkown
HY-RS12736 SESN3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21753 Sesn3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28271 Sesn3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SESN3 VGNC VGNC:34490
Rattus norvegicus SESN3 RGD RGD:1309470
Macaca mulatta SESN3 VGNC VGNC:77291
Canis familiaris SESN3 VGNC VGNC:46049
Felis catus SESN3 VGNC VGNC:65036
Mus musculus SESN3 MGD MGI:1922997
Others SESN3 NCBI