G6pc - glucose-6-phosphatase, catalytic Gene

Also Known as G6pt; G6pc1; G6Pase; Glc-6-Pase

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14377

Summary

The enzyme encoded by this gene is a multisubunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for glucose-6-phosphate, inorganic phosphate, and glucose. This gene is one of three glucose-6-phosphatase catalytic-subunit-encoding genes in mouse. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). [provided by RefSeq, Sep 2015]

G6pc Products (1)

mRNA Protein Name
NM_008061.4 NP_032087.2 glucose-6-phosphatase catalytic subunit 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables glucose-6-phosphatase activity IDA
IDA: Inferred from direct assay
8407995 MGI
enables glucose-6-phosphatase activity IMP
IMP: Inferred from mutant phenotype
8640227 MGI
enables phosphotransferase activity, alcohol group as acceptor IDA
IDA: Inferred from direct assay
8407995 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cholesterol homeostasis IMP
IMP: Inferred from mutant phenotype
8640227 MGI
involved in gluconeogenesis IMP
IMP: Inferred from mutant phenotype
33359667 MGI
acts upstream of or within glucose 6-phosphate metabolic process IMP
IMP: Inferred from mutant phenotype
8640227 MGI
acts upstream of or within glucose homeostasis IMP
IMP: Inferred from mutant phenotype
8640227 MGI
acts upstream of or within glucose-6-phosphate transport IDA
IDA: Inferred from direct assay
10625614 MGI
acts upstream of or within glucose-6-phosphate transport IMP
IMP: Inferred from mutant phenotype
8640227 MGI
acts upstream of or within glycogen catabolic process IMP
IMP: Inferred from mutant phenotype
10625614 MGI
acts upstream of or within glycogen metabolic process IMP
IMP: Inferred from mutant phenotype
8640227 MGI
acts upstream of or within multicellular organism growth IMP
IMP: Inferred from mutant phenotype
8640227 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
17588937 MGI
acts upstream of or within steroid metabolic process IMP
IMP: Inferred from mutant phenotype
17588937 MGI
acts upstream of or within triglyceride metabolic process IMP
IMP: Inferred from mutant phenotype
8640227 MGI
acts upstream of or within urate metabolic process IMP
IMP: Inferred from mutant phenotype
8640227 MGI
Cellular Component GO Annotation Evidence References Source
is active in endoplasmic reticulum IDA
IDA: Inferred from direct assay
8407995 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
10787428 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glucose-6-phosphatase catalytic subunit 1

  • Glc-6-Pase-alpha

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-15675 AZD1656 Activator 98.09% Phase 2

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05191 G6PC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05192 G6PC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05193 G6PC3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-186004 G6PC modulator-1 / Unkown
HY-RS20932 G6pc3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27449 G6pc3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown