G6pc - glucose-6-phosphatase, catalytic Gene

Mus musculus

Also known as G6pt; G6pc1; G6Pase; Glc-6-Pase

Gene ID: 14377 | Gene type: protein coding

About G6pc

Summary

The enzyme encoded by this gene is a multisubunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for glucose-6-phosphate, inorganic phosphate, and glucose. This gene is one of three glucose-6-phosphatase catalytic-subunit-encoding genes in mouse. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). [provided by RefSeq, Sep 2015]

G6pc Products(1)

mRNA	Protein	Name
NM_008061.4	NP_032087.2	glucose-6-phosphatase catalytic subunit 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables glucose-6-phosphatase activity	IDA IDA: Inferred from direct assay	8407995	MGI
enables glucose-6-phosphatase activity	IMP IMP: Inferred from mutant phenotype	8640227	MGI
enables phosphotransferase activity, alcohol group as acceptor	IDA IDA: Inferred from direct assay	8407995	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cholesterol homeostasis	IMP IMP: Inferred from mutant phenotype	8640227	MGI
involved in gluconeogenesis	IMP IMP: Inferred from mutant phenotype	33359667	MGI
acts upstream of or within glucose 6-phosphate metabolic process	IMP IMP: Inferred from mutant phenotype	8640227	MGI
acts upstream of or within glucose homeostasis	IMP IMP: Inferred from mutant phenotype	8640227	MGI
acts upstream of or within glucose-6-phosphate transport	IDA IDA: Inferred from direct assay	10625614	MGI
acts upstream of or within glucose-6-phosphate transport	IMP IMP: Inferred from mutant phenotype	8640227	MGI
acts upstream of or within glycogen catabolic process	IMP IMP: Inferred from mutant phenotype	10625614	MGI
acts upstream of or within glycogen metabolic process	IMP IMP: Inferred from mutant phenotype	8640227	MGI
acts upstream of or within multicellular organism growth	IMP IMP: Inferred from mutant phenotype	8640227	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	17588937	MGI
acts upstream of or within steroid metabolic process	IMP IMP: Inferred from mutant phenotype	17588937	MGI
acts upstream of or within triglyceride metabolic process	IMP IMP: Inferred from mutant phenotype	8640227	MGI
acts upstream of or within urate metabolic process	IMP IMP: Inferred from mutant phenotype	8640227	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in endoplasmic reticulum	IDA IDA: Inferred from direct assay	8407995	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	10787428	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

glucose-6-phosphatase catalytic subunit 1

Glc-6-Pase-alpha

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15675	AZD1656	Activator	98.09%	Phase 2

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05191	G6PC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05192	G6PC2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05193	G6PC3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-186004	G6PC modulator-1		/	Unkown
HY-RS20932	G6pc3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27449	G6pc3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

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