Gabpa - GA repeat binding protein, alpha Gene

Also Known as GABPalpha

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14390

Summary

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and chromatin binding activity. Acts upstream of or within blastocyst formation; negative regulation of megakaryocyte differentiation; and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human GABPA (GA binding protein transcription factor subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]

Gabpa Products (1)

mRNA Protein Name
NM_008065.2 NP_032091.2 GA-binding protein alpha chain

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
11004506 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
16757682 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within blastocyst formation IMP
IMP: Inferred from mutant phenotype
27869233 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
17485447 MGI
acts upstream of or within negative regulation of megakaryocyte differentiation IMP
IMP: Inferred from mutant phenotype
16757682 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17485447 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15361867 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
11004506 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

GA-binding protein alpha chain

  • GA-binding protein alpha-subunit

  • GABP subunit alpha

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05206 GABPA Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gabpa NCBI NCBI:2551