2. Gene
  3. Gabrb1 - gamma-aminobutyric acid (GABA) A receptor, subunit beta 1 Gene

Gabrb1 - gamma-aminobutyric acid (GABA) A receptor, subunit beta 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Gabrb-1; B230208N19Rik

Gene ID: 14400 | Gene type: protein coding

About Gabrb1

Summary

Predicted to enable GABA Receptor binding activity; GABA-gated chloride ion channel activity; and transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to contribute to GABA-A receptor activity and Chloride Channel activity. Predicted to be involved in several processes, including cellular response to histamine; chloride transmembrane transport; and gamma-aminobutyric acid signaling pathway. Predicted to act upstream of or within chloride transport. Predicted to be located in several cellular components, including dendrite; nuclear envelope; and plasma membrane. Predicted to be part of GABA-A receptor complex. Predicted to be active in neuron projection and synapse. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in autistic disorder and developmental and epileptic encephalopathy 45. Orthologous to human GABRB1 (gamma-aminobutyric acid type A receptor subunit beta1). [provided by Alliance of Genome Resources, Apr 2022]

Gabrb1 Products(2)

mRNA Protein Name
NM_001370968.1 NP_001357897.1 gamma-aminobutyric acid receptor subunit beta-1 isoform 2
NM_008069.5 NP_032095.1 gamma-aminobutyric acid receptor subunit beta-1 isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential EXP
EXP: Inferred from Experiment
11498050 MGI
enables G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential IDA
IDA: Inferred from direct assay
11498050 MGI
enables G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential IMP
IMP: Inferred from mutant phenotype
11498050 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in GABA-ergic synapse EXP
EXP: Inferred from Experiment
11498050 MGI
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
11498050 MGI
is active in GABA-ergic synapse IMP
IMP: Inferred from mutant phenotype
11498050 MGI
is active in Schaffer collateral - CA1 synapse EXP
EXP: Inferred from Experiment
11498050 MGI
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
11498050 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
11498050 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

gamma-aminobutyric acid receptor subunit beta-1

GABA(A) receptor subunit beta-1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05215 GABRB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gabrb1 NCBI NCBI:2560